Projects

Exploring alternative indicators for trachoma endpoint decision-making (Tanzania)

Analyze the relationships between the prevalence of the clinical sign follicular trachoma (TF) and the prevalence of infection and antibody to determine whether it may be appropriate to consider one or more alternative indicators for deciding whether trachoma programs can stop MDA.

Countries: Tanzania
Diseases: Trachoma

Exploring alternative indicators for trachoma endpoint decision-making (Uganda)

Analyze the relationships between the prevalence of the clinical sign follicular trachoma (TF) and the prevalence of infection and antibody to determine whether it may be appropriate to consider one or more alternative indicators for deciding whether trachoma programs can stop MDA.

Countries: Uganda
Diseases: Trachoma

Exploring alternative indicators for trachoma endpoint decision-making (Malawi)

Analyze the relationships between the prevalence of the clinical sign follicular trachoma (TF) and the prevalence of infection and antibody to determine whether it may be appropriate to consider one or more alternative indicators for deciding whether trachoma programs can stop MDA.

Countries: Malawi
Diseases: Trachoma

Development and validation of sampling strategies for xenomonitoring of infection in Culex vector by PCR as a surveillance tool for assessing post-MDA lymphatic filariasis transmission

Develop and validate sampling strategies for monitoring vector infection that would be useful to evaluate the success of LF-elimination programmes.

Findings and Lessons Learned:

This represents a follow-up to a longitudinal study with data collection in 2010 and 2012 (previous funding) and now with a third time point in 2015. At all 3 time points a rigorous mosquito sampling protocol was applied and the results were analyzed to detect filarial DNA by PCR. To test the reproducibility of the results, at each time point the survey teams conducted two independent, sequential samples of approximately 11,000 mosquitoes each. In addition to surveying the entire PHC area, a nested hotspot survey was conducted in areas where there has been historically high transmission. One very important outcome of this study is the development of a standardized protocol for sampling culex mosquitoes that is statistically rigorous and reproducible. The study showed that MX can be a valuable tool for monitoring decreasing prevalence over-time. The authors propose a threshold of 0.5% in culex be used to measure 0% Ag prevalence in children for stopping MDA.

Countries: India

Trachoma Post- MDA Surveillance Project

To validate thresholds for stopping MDA and improve confidence that elimination goals have been achieved through post-MDA surveillance.

Countries: Nepal
Diseases: Trachoma

Systematic Comparison of MF and Ab Prevalence by Age, Post-MDA

To validate the Brugia antibody tests as a tool for stopping LF MDA.

Countries: Indonesia

Development of novel survey methodology for re-mapping LF in low prevalence areas (Ethiopia)

Demonstrate the utility of a new mapping strategy based on school cluster random sampling Using PPES. A secondary objective is to assess the value of laboratory-based antibody assays as confirmatory tests and additional diagnostic tools for measuring LF transmission. 

Countries: Ethiopia

Randomized Control Trial Comparing Efficacy of a Single Dose of Treatment of Yaws with 20 mg/kg Versus 30 mg/kg of Azithromycin

Non-inferiority study comparing a 20mg/kg dosing strategy of azithromycin to a 30mg/kg dosing strategy in the treatment of yaws 

Countries: Papua New Guinea | Ghana
Diseases: Yaws

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