Projects

Comparison of muti-parallel qPCR and Kato-Katz for detection of STH in Kenyan children

Is the multiparallel quantitative polymerase chain reaction technique superior to Kato-Katz microscopy in assessing the intensity and prevalence of soil-transmitted helminth infections in stool?

Preliminary Findings and Lessons Learned

  • qPCR was more sensitive than Kato-Katz at detecting Ascaris, Trichuris, and hookworm infections in child fecal samples.
  • Very few samples were helminth positive by Kato-Katz microscopy that were not also positive by qPCR, suggesting minimal human classification error during microscopy.
  • Duplicate qPCR analysis on ~10% of samples by two separate labs (Smith and KEMRI) showed excellent concordance (97-100% agreement for each helminth species).
  • A reanalysis of the effect of a combined water, sanitation, and hand washing (WASH) intervention on child helminth infections with qPCR data compared to Kato-Katz data gave very similar results.
Countries: Kenya

Development of a Mobile Reader for Rapid Diagnostic Tests

Can a mobile reader be used to standardize the reading of rapid diagnostic tests (RDTs)?

Doxycycline for Clinical Management of Filarial Lymphedema (Mali)

Determine whether doxycycline treatment daily for 6 weeks improves clinical outcomes (swelling, acute attacks) in lymphedema patients.

Countries: Mali

Doxycycline for Clinical Management of Filarial Lymphedema (Sri Lanka)

Determine whether doxycycline treatment daily for 6 weeks improves clinical outcomes (swelling, acute attacks) in lymphedema patients.

Countries: Sri Lanka

Co-Endemicity of Lymphatic Filariasis and Loiais in the Republic of Congo

Determine Co-Endemicity of Lymphatic Filariasis and Loiais in the Republic of Congo

Countries: Congo

Schistosoma Prevalence in Mekong River Basin of Cambodia and Laos Border

Determine the Schistosoma prevalence in the Mekong River Basin on the border of Laos and Cambodia

Diseases: Schistosomiasis

Evaluation of Schistosomiasis RDT (CCA) in DRC

To complete mapping of NTDs in AFRO and support transitioning of new diagnostics tools into program use.

Countries: Dem. Rep. of Congo
Diseases: Schistosomiasis

Correlation of Xenomonitoring and LF-Antibody Responses as Measures of Transmission in American Samoa

Determine the utility of xenomonitoring and serological assessments for the detection of residual transmission

Countries: American Samoa

Pages