Soil-transmitted helminthiasis

Integrating NTD programme monitoring into routine health systems data: evaluating a DHIS2 platform for real-time mass administration of medicines (MAM) reporting

This study includes an assessment of the Sightsavers rollout of a DHIS2 based tool for data collection in the NTD program in 2 states in Nigeria. In particular, the research project seeks to evaluate the health system strengthening effects of the tool for planning, monitoring and reporting of MDA. They plan to examine:

  1. the functionality of the tool at scale
  2. ease of integration across different NTD interventions
  3. data accessibility, accuracy, timeliness, and usefulness.

The team also aims to understand whether the implementation of this tool would enhance government ownership of the data and the NTD programme in general. This research will aid in identifying barriers and opportunities for potential scale up of the tool throughout Nigeria. The team also plans to focus on understanding how the data will be used at different levels of the health system.

Countries: Nigeria

The Zambia Neglected Tropical Disease Control Programme’s role in the attainment of Universal Health Coverage in Zambia: an implementation research study.

This study aims to conduct a landscape analysis to better understand the implementation context for the NTD control programme in Zambia. The activities include:

  1. an assessment of institutional structures, service delivery systems, existing resources/capacity
  2. mapping gaps, facilitators, and barriers to program implementation
  3. identifying potential opportunities to introduce innovative approaches for program integration and improvement.

Key informant interviews and focus group discussions with policy makers and NTD program officers will complement an extensive document review. The results of this assessment will be fed into the next National Health Strategic Plan, which expires in 2021.

Countries: Zambia

Integrating spatial analysis in mixed methods approach to improve MDA Access by reaching underserved and vulnerable populations of Mali in NTD elimination framework

This mixed methods study plans to focus activities around two kinds of mobile, underserved populations: nomadic pastoralists in the rural district of Tominian and economic migrants and displaced groups from conflict areas in the urban district of Kalabancoro. Activities include:

  1. Quantitative questionnaire with a micro-narrative component. Micro-narratives are an established methodology focused on rapidly collecting qualitative data from a large number of participants
  2. Spatial analysis of study participants
  3. In-depth interviews and focus group discussions with health workers and community/opinion leaders
  4. Integrated analysis of the spatial data with questionnaire and micro-narrative data to better describe trends in the targeted vulnerable populations with respect to accessibility and acceptability of NTD program services

The team aims to combine spatial analysis with qualitative data collection to answer the following research questions:

  1. What are the factors leading to low coverage of MDA within underserved and vulnerable populations in Malian community?
  2. How are underserved and vulnerable populations currently being served by the public health interventions/health system?
  3. How effective and efficient is the ISAMA process for NTDs coverage in underserved and vulnerable populations compared to the current data collection and analysis approach?
  4. What critical factors influence the use of ISAMA approach in data analysis system process?
  5. How are characteristics of low coverage geographically distributed and the factors associated in underserved and vulnerable populations?
  6. Who are the underserved populations and what are their characteristics?
Countries: Mali

Assessing the effectiveness of using the Community Directed Intervention (CDI) approach to improve community ownership of Mass Drug Administration (MDA) for Neglected Tropical Diseases (NTDs) in Malawi

This project intends to assess the effectiveness of using the Community Directed Intervention (CDI) approach as a vehicle for delivery of mass drug administration (MDA) campaigns against targeted NTDs namely, schistosomiasis and soil-transmitted helminths (STH) such as Ascaris lumbricoides (roundworms), Trichuris trichiura (whip worms) and Ancylostoma sp. (hookworms) in selected districts of Malawi. The idea is to take advantage of the logistical setup, organizational strength and high degree of efficiency of the national NTD programme to improve delivery of the current MDA efforts to control selected and highly prioritized NTDs of schistosomiasis and STH and to enhance community ownership of the interventions in selected rural and remote communities by using the CDI approach. The primary research question is: Can the CDI approach be effectively used to deliver MDA to control NTDs at community level in rural Malawian districts?

Countries: Malawi

Collaborative effort to address intestinal worms through education, medical care, health assessments, quizzes/contests in school

The effectiveness of motivating locals to address intestinal worms through education, medical care and health assessments.

Countries:

Is Preventive Chemotherapy for NTDs Really “Pro-Poor?”: Insights from the Demographic and Health Surveys

To use DHS data from 40 countries to examine the extent to which deworming of children 1-4 years is associated with: 1) a range of individual- and family-related socioeconomic indicators, including wealth quintile and maternal education; and 2) access to health systems that could provide opportunities for deworming, independent of family-level socioeconomic status.

Countries:

Sustaining the Gains of NTD elimination programs through focused support of community drug distributors

To sustain the gains of active community drug distributors (CDDs) by enhancing their performance through intervention at the individual, community and primary health care center levels to reach NTD elimination and control goals.

Countries: Uganda | Cote d'Ivoire

Development of a molecular diagnostic method for soil-transmitted helminthiases: Epidemiological implications for disease control

To improve STH detection by developing a reliable and easy to perform molecular diagnostic test for epidemiological surveillance and post-elimination monitoring of STH

Countries: Cameroon

DeWorm3 Implementation Science

The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of STH interventions.

The purpose of DeWorm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. Research methods include: (1) stakeholder mapping and network analysis, (2) qualitative research, (3) structural readiness surveys, (4) process mapping, and (5) economic evaluation (costing and cost-effectiveness). 

 Implementation science research aims include:

1)To systematically identify stakeholders influencing standard of care targeted and community-wide MDA and map their potential role and involvement in scale-up of community-wide MDA for STH.

2)To identify implementation-related barriers and facilitators to community-wide MDA for STH from the perspective of various stakeholders.

3)To quantify the readiness of the health system to deliver community-wide MDA for STH programs.

4)To map the intervention delivery process and identify any discrepancies between planned and implemented activities in order to optimize the trial intervention.

5)To compare the financial and economic costs and incremental cost-effectiveness of community-wide and targeted MDA for STH in the short- and long-term.

 

Countries: Benin | Malawi | India

Starworms study

The Starworms project aims to strengthen the monitoring and surveillance of drug efficacy and anthelmintic resistance in soil-transmitted helminth (STH) programs. As such, it will support deworming programs in their quest to eliminate STHs as a public health problem by 2020. The specific objectives are (1) to validate diagnostic tools to monitor drug efficacy and the spread of anthelmintic resistance, (2) to create a surveillance system that monitors the global patterns of drug efficacy and spread of anthelmintic resistance in STH programs, and (3) to develop supporting tools to plan, analyze and follow up on surveys on drug efficacy and the spread of anthelmintic resistance.

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