Schistosomiasis
Mapping schistosomiasis and soil-transmitted helminthiasis in Namibia
Assessing treatment needs for school-aged children and assisting Ministry of Health to develop an effective control programme
Drug formulation for pre-school children
Understanding the basic pharmacology of praziquantel tailored to paediatric setting and developing a treatment access plan for this age class
COUNTDOWN Calling
Helping increase and sustain the scale-up of preventive chemotherapy campaigns in West and Central Africa
Strengthen the capacity of the 5 African university departments hosting the MCDC programme
To strengthen the capacity of the 5 African university departments hosting the Malaria Capacity Development Consortium (MCDC) programme
Interventions in Persistent Hot-Spots in Kenya
Will providing enhanced MDA at the community level while achieving treatment coverage of 75% or greater in children (5-17) and adults substantially decrease S. mansoni infection in previously identified persistent hot-spot communities?
Xenomonitoring Surveillance
Is molecular detection of schistosome infection (patent and pre-patent) in snails a useful tool for program managers as prevalence and intensity of infection in people approaches very low levels?
Interventions in Persistent Hot-Spots in Tanzania
How do villages which do not show substantial decreases in the prevalence of schistosomiasis despite repeated, high coverage mass drug administration (persistent hot-spot villages) differ from villages which show substantial decrease in prevalence across various factors (declining prevalence villages)?
Economic analysis in SCORE projects
Economic evaluation of SCORE projects with priority given to elimination studies
Identification of serosurveilance antigens for schistosomiasis
To identify antigens that can be produced as recombinant proteins and to document elimination of schistosomiasis.
To identify antigens that differentiate between infections with Schistosoma mansoni and Schistosoma haematobium and that can be used in an ELISA, lateral flow assay or multiplex format.
Single vs. multiple treatments of praziquantel in intestinal African schistosomiasis: a randomized, double-blind, placebo controlled trial investigation using new diagnostic tools
Rigorous assessment of the efficacy of (multiple) doses with Praziquantel in the treatment of S. mansoni infections using standard and novel highly sensitive diagnostic tools.