Whole genome sequencing of ocular Chlamydia trachomatis in Amhara region, Ethiopia, an area with persistent hyperendemic trachoma.
This study will address the characteristics of the ocular chlamydia trachomatis population structures within Amhara, a setting which has experienced repeated rounds of antibiotic for trachoma, and whether those circulating populations are different than known sequenced strains.
Assessing treatment needs for school-aged children and assisting Ministry of Health to develop an effective control programme
Understanding the basic pharmacology of praziquantel tailored to paediatric setting and developing a treatment access plan for this age class
Helping increase and sustain the scale-up of preventive chemotherapy campaigns in West and Central Africa
Is molecular detection of schistosome infection (patent and pre-patent) in snails a useful tool for program managers as prevalence and intensity of infection in people approaches very low levels?
Develop genetic markers for S. haematobium
Schistosome Population Genetics in Gaining Control Studies in Niger (Sh) and Tanzania (Sm)
Gaining Control: >25% Prevalence MDA strategies; and subtle morbidity of Cohort; Population genetics, and snail monitoring
Sustaining / Gaining Control with Single versus Double Treatment; and Population genetics, snail monitoring