Other study design
Whole genome sequencing of ocular Chlamydia trachomatis in Amhara region, Ethiopia, an area with persistent hyperendemic trachoma.
This study will address the characteristics of the ocular chlamydia trachomatis population structures within Amhara, a setting which has experienced repeated rounds of antibiotic for trachoma, and whether those circulating populations are different than known sequenced strains.
Production of a New Dual Antigen Test Strip as a Tool to Support Epidemiologic Assessments of Onchocerciasis
How does the performance of the new Ov16/Ov3261 test strip compare to that of the SD Ov16 RDT and the SD Ov16 ELISA?
Improving Mass Drug Administration After Transmission Assessment Survey Failure: Results from a Mixed Methods Study
- What factors are associated with the availability, accessibility, and acceptability of MDA?
- What is the impact of an adapted and tailored intervention package on effective coverage?
Towards sustainability of Schistosomiasis Control: improving health of lake shore communities and engaging civil society structures, educational and health facilities in the hyper-endemic area of Mwanza, Tanzania
Schistosomiasis is among the neglected tropical diseases which are highly endemic in Tanzania, especially along and on the Island of Lake Victoria, in northwestern region. After Nigeria, Tanzania is second country in sub-Saharan Africa for having the highest prevalence of schistosomiasis infection and it is estimated that 52% of approximately 50 million people are living with the disease. Current control strategies in Tanzania focus on mass drug administration (MDA) of Praziquantel (PZQ) mainly in school children. Despite of these efforts, the burden of disease remains high, showing local infection rates of up to 97% among school children. School- based MDA alone is unlikely to have a lasting effect on transmission. Awareness creation and engagement across sectors and of civil society (cooperatives, community councils) structures will help to achieve more sustainable results. The objective of this project is to engage affected communities and civil society structures representing risk population (cooperatives, beach management units) to create awareness through e.g. CHAST (children’s hygiene and sanitation training), participation in control activities and improved health seeking behaviors. Secondarily, the study aims to institutionalize measures for early diagnosis and treatment in health facilities of Nyamagana and Ilemela district, along the Lake Victoria, northwestern Tanzania.
To increase onchocerciasis treatment coverage and to optimize service delivery through community mobilization, disease sensitization, training and strengthening of community health extension workers (CHEW), and community control advocates
Investigation of possible ongoing Schistosoma hybridization in Nigeria and implications for response to treatment
To investigate the presence and epidemiology of Schistosoma hybrids in Nigeria. The acquisition of new genes through hybridization may generate new phenotypes that might differ in virulence, drug resistance, pathology, and host use, ultimately leading to the emergence of new diseases. Hybrids can develop into a new emerging pathogen, necessitating new control strategies in zones where both parental species overlap, an intense and rapid control response is required to minimize further spread of the hybrid and possible escalation of human schistosomiasis.
To evaluate 3D photographs of trachomatous trichiasis (TT) in the training and assessment of trachoma graders.
Through funding from the Wellcome Trust to develop a global atlas of podoconiosis. We aim to advance new knowledge on the geographical distribution and spatial epidemiology of the disease.
i. Conduct national cross-sectional surveys in selected countries to validate the environmental predictive model developed using the mapping data in Ethiopia.
ii. Create evidence consensus maps, develop risk maps and ground-truthing work and delineate the spatial distribution and geographical limits of podoconiosis globally.
iii. Estimate the global burden of podoconiosis by quantifying the number affected, the population at risk and DALYs attributable.
iv. Estimate how much it will cost to control or eliminate podoconiosis globally.
The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of STH interventions.
The purpose of DeWorm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. Research methods include: (1) stakeholder mapping and network analysis, (2) qualitative research, (3) structural readiness surveys, (4) process mapping, and (5) economic evaluation (costing and cost-effectiveness).
Implementation science research aims include:
1)To systematically identify stakeholders influencing standard of care targeted and community-wide MDA and map their potential role and involvement in scale-up of community-wide MDA for STH.
2)To identify implementation-related barriers and facilitators to community-wide MDA for STH from the perspective of various stakeholders.
3)To quantify the readiness of the health system to deliver community-wide MDA for STH programs.
4)To map the intervention delivery process and identify any discrepancies between planned and implemented activities in order to optimize the trial intervention.
5)To compare the financial and economic costs and incremental cost-effectiveness of community-wide and targeted MDA for STH in the short- and long-term.
How do we motivate community drug distributors (CDDs)?