Other research topic

Investigation of possible ongoing Schistosoma hybridization in Nigeria and implications for response to treatment

To investigate the presence and epidemiology of Schistosoma hybrids in Nigeria. The acquisition of new genes through hybridization may generate new phenotypes that might differ in virulence, drug resistance, pathology, and host use, ultimately leading to the emergence of new diseases. Hybrids can develop into a new emerging pathogen, necessitating new control strategies in zones where both parental species overlap, an intense and rapid control response is required to minimize further spread of the hybrid and possible escalation of human schistosomiasis.

Countries: Nigeria
Diseases: Schistosomiasis

Long term outcome of the two most commonly used surgical procedures to treat trachomatous trichiasis (TT): PLTR vs BLTR

Ascertain whether the difference in outcome (measured in rate of post-operative trachomatous trichiasis, or TT), between the posterior lamellar tarsal rotation (PLTR) and bilamellar tarsal rotation (BLTR) is sustained at four years or whether they give different results from what has been found at 1 year.

Countries: Ethiopia
Diseases: Trachoma

Quality and quantity of post-epilation trichiatic lashes: a cohort study

To understand the nature (quality and quantity) of post epilation lashes and their visual significance in unoperated minor trachomatous trichiasis (TT) cases and case with post-operative trichiasis

Countries: Ethiopia
Diseases: Trachoma

DeWorm3 Implementation Science

The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of STH interventions.

The purpose of DeWorm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. Research methods include: (1) stakeholder mapping and network analysis, (2) qualitative research, (3) structural readiness surveys, (4) process mapping, and (5) economic evaluation (costing and cost-effectiveness). 

 Implementation science research aims include:

1)To systematically identify stakeholders influencing standard of care targeted and community-wide MDA and map their potential role and involvement in scale-up of community-wide MDA for STH.

2)To identify implementation-related barriers and facilitators to community-wide MDA for STH from the perspective of various stakeholders.

3)To quantify the readiness of the health system to deliver community-wide MDA for STH programs.

4)To map the intervention delivery process and identify any discrepancies between planned and implemented activities in order to optimize the trial intervention.

5)To compare the financial and economic costs and incremental cost-effectiveness of community-wide and targeted MDA for STH in the short- and long-term.

 

Countries: Benin | Malawi | India

Studies of Gene Expression Pattern of Glutathione-S-Transferase (OvGST1) in the host and vector Simulium damnosum s.l.

To study the glutathione-S-transferase (OvGST1) gene expression pattern in the life cycle stages critical for the establishment of infection by Onchocerca volvulus.

Countries: Nigeria
Diseases: Onchocerciasis

Mechanism to reverse the neglect of snakebite victims

To understand the mechanism to reverse the neglect of snakebite victim

Countries:
Diseases: Snakebite

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