Other research topic

Addressing the Mental Health of Persons Living with Lymphatic Filariasis in Léogâne, Haiti: Effectiveness of a Chronic Disease Self-Management Program

Intervention: The primary aim of this project is to determine if the introduction of a Chronic Disease Self-Management curriculum into existing Hope Clubs in Léogâne, Haiti will result in improvements in symptoms of depression, self-rated health, chronic disease self-efficacy, social support, and disability.

Formative: What are the barriers that prevent people with LF from participating in Hope Clubs?

Countries: Haiti

Towards sustainability of Schistosomiasis Control: improving health of lake shore communities and engaging civil society structures, educational and health facilities in the hyper-endemic area of Mwanza, Tanzania

Schistosomiasis is among the neglected tropical diseases which are highly endemic in Tanzania, especially along and on the Island of Lake Victoria, in northwestern region. After Nigeria, Tanzania is second country in sub-Saharan Africa for having the highest prevalence of schistosomiasis infection and it is estimated that 52% of approximately 50 million people are living with the disease. Current control strategies in Tanzania focus on mass drug administration (MDA) of Praziquantel (PZQ) mainly in school children. Despite of these efforts, the burden of disease remains high, showing local infection rates of up to 97% among school children. School- based MDA alone is unlikely to have a lasting effect on transmission. Awareness creation and engagement across sectors and of civil society (cooperatives, community councils) structures will help to achieve more sustainable results. The objective of this project is to engage affected communities and civil society structures representing risk population (cooperatives, beach management units) to create awareness through e.g. CHAST (children’s hygiene and sanitation training), participation in control activities and improved health seeking behaviors. Secondarily, the study aims to institutionalize measures for early diagnosis and treatment in health facilities of Nyamagana and Ilemela district, along the Lake Victoria, northwestern Tanzania.

Countries: Tanzania
Diseases: Schistosomiasis

Monitoring migrant groups as a post-treatment surveillance approach to contain the potential risk of lymphatic filaraisis re-emergence after stopping mass drug administration in Togo

In March 2016, the Republic of Togo submitted an application for validation of the elimination of LF as a public health problem. However, healthcare facility managers in some health regions – especially in the Savanes Region, have reported the presence of migrant groups from neighboring countries which are still endemic to LF – i.e. Ghana, Burkina Faso, Nigeria. Migrants arrive and reside temporarily but recurrently in some localities of these regions. They constitute hotspots that can be source of resurgence, mainly because the nationwide passive surveillance has been stopped in 2016. 

In order to track all population movements that constitute a potential risk to the Republic of Togo, the country proposes to set up a strategy for the identification of these groups, with the contribution of Neglected Tropical Disease (NTD) Focal Points, followed by the research of potential parasite carriers. Isolated cases discovered will be investigated in order to track all imported W. bancrofti. They will be treated, but if an effective hotspot is discovered, rounds of Albendazole and Ivermectin MDA will be implemented a follow up of infected individuals will be maintained. 

The purpose of this study is to contribute maintaining the end of LF transmission across the country.

Countries: Togo

Investigation of possible ongoing Schistosoma hybridization in Nigeria and implications for response to treatment

To investigate the presence and epidemiology of Schistosoma hybrids in Nigeria. The acquisition of new genes through hybridization may generate new phenotypes that might differ in virulence, drug resistance, pathology, and host use, ultimately leading to the emergence of new diseases. Hybrids can develop into a new emerging pathogen, necessitating new control strategies in zones where both parental species overlap, an intense and rapid control response is required to minimize further spread of the hybrid and possible escalation of human schistosomiasis.

Countries: Nigeria
Diseases: Schistosomiasis

Long term outcome of the two most commonly used surgical procedures to treat trachomatous trichiasis (TT): PLTR vs BLTR

Ascertain whether the difference in outcome (measured in rate of post-operative trachomatous trichiasis, or TT), between the posterior lamellar tarsal rotation (PLTR) and bilamellar tarsal rotation (BLTR) is sustained at four years or whether they give different results from what has been found at 1 year.

Countries: Ethiopia
Diseases: Trachoma

Quality and quantity of post-epilation trichiatic lashes: a cohort study

To understand the nature (quality and quantity) of post epilation lashes and their visual significance in unoperated minor trachomatous trichiasis (TT) cases and case with post-operative trichiasis

Countries: Ethiopia
Diseases: Trachoma

DeWorm3 Implementation Science

The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of STH interventions.

The purpose of DeWorm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. Research methods include: (1) stakeholder mapping and network analysis, (2) qualitative research, (3) structural readiness surveys, (4) process mapping, and (5) economic evaluation (costing and cost-effectiveness). 

 Implementation science research aims include:

1)To systematically identify stakeholders influencing standard of care targeted and community-wide MDA and map their potential role and involvement in scale-up of community-wide MDA for STH.

2)To identify implementation-related barriers and facilitators to community-wide MDA for STH from the perspective of various stakeholders.

3)To quantify the readiness of the health system to deliver community-wide MDA for STH programs.

4)To map the intervention delivery process and identify any discrepancies between planned and implemented activities in order to optimize the trial intervention.

5)To compare the financial and economic costs and incremental cost-effectiveness of community-wide and targeted MDA for STH in the short- and long-term.

 

Countries: Benin | Malawi | India

Studies of Gene Expression Pattern of Glutathione-S-Transferase (OvGST1) in the host and vector Simulium damnosum s.l.

To study the glutathione-S-transferase (OvGST1) gene expression pattern in the life cycle stages critical for the establishment of infection by Onchocerca volvulus.

Countries: Nigeria
Diseases: Onchocerciasis

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