Onchocerciasis

Evaluation of MDA restart in the context of COVID-19 in Kwara and Kano, Nigeria

1. Can MDA resume and achieve high performance while minimizing risk of COVID-19 transmission through adherence to SOPs?

2. Can local teams easily implement the recommended modifications to MDAs; what is the added cost; and how do the above vary by context?

3. What aspects of local context influence implementation of SOPs?

Countries: Nigeria

Onchocerciasis LAMP assay to optimize diagnostics and sampling strategies for low-prevalence settings in Cameroon

Primary

1. Can the O-150 LAMP assay be established on whole blood? 2. Can the O-150 qPCR methodology be adapted for human sampling?

Secondary

1. How does the performance of the O-150 LAMP compare to the O-150 qPCR assay?

2. What threshold be used to define positive vs negative results for both assays?

3. Can deep sequencing reveal over potential biomarkers for further investigation?

Countries: Cameroon
Diseases: Onchocerciasis

High-Sensitivity, High-Specificity Biplex Ov16/OVOC3261 Rapid Diagnostic Test

  • An Ov16/OVOC3261 biplex IgG4 test, whereby we are confident that we can provide > 60% sensitivity and 99.8% specificity, as required by the TPP for Onchocerciasis Elimination Mapping.
  • Demonstration that the Ov16/OVOC3261 biplex IgG4 test behaves at least as good with blood as with plasma/serum samples (notably a perceived weakness of the SD Ov16 RDT)
Diseases: Onchocerciasis

Evaluation of MDA restart in the context of COVID-19 in Benin

1. Can MDA resume and achieve high performance while minimizing risk of COVID-19 transmission through adherence to SOPs?

2. Can local teams easily implement the recommended modifications to MDAs; what is the added cost; and how do the above vary by context?

3. What aspects of local context influence implementation of SOPs?

 

Countries: Benin

Evaluating the adoption of COVID-19 prevention measures during mass drug administration in Anambra State, Nigeria

Are NTD programs in Anambra State, Nigeria, adopting and implementing prevention measures for COVID-19 in their drug delivery activities? What adaptations are required by staff and volunteers to adopt these measures? What are the barriers to doing so? What are the incremental costs associated with conducting MDA during a global pandemic?

Countries: Nigeria

Xenomonitoring of black flies to confirm serologic threshold for onchocerciasis elimination mapping

To determine the appropriate serologic threshold(s) to be used to initiate MDA for onchocerciasis.

Countries: Ethiopia
Diseases: Onchocerciasis

Evaluation of community directed vector control on transmission of Onchocerca volvulus in a Loa loa co-endemic region

This study will pilot the Slash and Clear methodology in an oncho-Loa loa co-endemic setting. Previous pilots in Uganda and Nigeria have demonstrated that this simple strategy of removing breeding sites can result in significant black fly reductions that last for several months. This study will provide important data on the impact of Slash and Clear on black fly biting, and consequently its impact on oncho elimination. Two intervention and one control community will be compared for two years, with repeated measurements being taken of biting rates.

Countries: Cameroon
Diseases: Loiasis | Onchocerciasis

Xenomonitoring of black flies to confirm serologic threshold for onchocerciasis elimination mapping

To determine the appropriate serologic threshold(s) to be used to initiate MDA for onchocerciasis

Countries: Malawi
Diseases: Onchocerciasis

Community participatory action research to increase MDA coverage in hard-to-reach urban populations

Urban dwellers have frequently been included as "hard to reach" when examining MDA coverage and uptake. Poor coverage in urban settings is a key factor that prevents programs in some settings from achieving success. This research study proposes a community-based participatory action research (CBPAR) strategy to better understand the reasons why this population isn’t reached and/or their decision not to participate in onchocerciasis and lymphatic filariasis MDAs. The results will help identify last mile strategies for urban populations and will generate a technical toolkit for how to conduct rapid participatory research in areas that require novel outreach methods amongst hard-to-reach populations. This form of social science methodology has not been used frequently within the NTD community and this proposal offers an opportunity to build the evidence base for these methods within the context of hard to reach populations.

The researchers plan to conduct a number of activities in order to determine the effectiveness of the participatory approach in targeting urban populations as compared to the standard mobilization and delivery approach.

  1. Rapid ethnographic interviews, a new technique aimed at rapidly collecting and analyzing qualitative data, to gather community feedback regarding barriers in accessing treatment
  2. An intervention development workshop with community leaders, health workers, researchers, and the ministry of health
  3. Deliver the newly designed strategy in Za-Kpota district and compare coverage in urban settings to Ouinhi district
  4. Finalize a rapid participatory approach toolkit and conduct a time-motion study of the approach to improve the business case to the MoH for uptake 5. Surveys and individual interviews with key stakeholders to determine acceptability, appropriateness, and feasibility of the proposed approach and toolkit
Countries: Benin

Improving disease control and elimination decision making with geospatial algorithms

Can geospatial algorithms be used by disease programs to help identify hotspots at community and Implementation Unit level?

Countries:

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