Mapping the Potential Risk of Mycetoma Infection in Sudan and South Sudan Using Ecological Niche Modeling
What is the potential distribution of mycetoma in Sudan and South Sudan? What are the most important factors associated with the spatial distriutional patterns of disease cases in Both countries.
Understanding areas of increased trachoma risk (hotspots) through the implementation of a post validation trachoma surveillance strategy
To determine if there is evidence of on-going or recent transmission in the “hotspot” communities of increased risk two years after they were identified during the pre-validation surveys (clinical, antibody and infection data).
To identify the sampling strategy for positive case follow-up after TAS 2 and TAS 3 that optimizes the chances of correctly identifying evidence of ongoing transmission, while saving program resources.
Investigation of possible ongoing Schistosoma hybridization in Nigeria and implications for response to treatment
To investigate the presence and epidemiology of Schistosoma hybrids in Nigeria. The acquisition of new genes through hybridization may generate new phenotypes that might differ in virulence, drug resistance, pathology, and host use, ultimately leading to the emergence of new diseases. Hybrids can develop into a new emerging pathogen, necessitating new control strategies in zones where both parental species overlap, an intense and rapid control response is required to minimize further spread of the hybrid and possible escalation of human schistosomiasis.
Can routine reports be used to identify hot spots of scabies transmission?
Studies of Gene Expression Pattern of Glutathione-S-Transferase (OvGST1) in the host and vector Simulium damnosum s.l.
To study the glutathione-S-transferase (OvGST1) gene expression pattern in the life cycle stages critical for the establishment of infection by Onchocerca volvulus.
Deliver at least one novel pre-clinical candidate capable of delivering a macrofilaricide treatment for onchocerciasis (and lymphatic filariasis) within a seven-day treatment period or less.
Establish the best registered drug for deployment as a macrofilaricide alone and/or in combination with standard anti-filarial drugs.
Late lead optimisation
Establish the most promising template for final lead optimization from a screen of >10000 compounds from the BioFocus library which revealed compounds with very good anti-Wolbachia activity.