Drugs & Diagnostics for Tropical Diseases (DDTD)

High-Sensitivity, High-Specificity Biplex Ov16/OVOC3261 Rapid Diagnostic Test

  • An Ov16/OVOC3261 biplex IgG4 test, whereby we are confident that we can provide > 60% sensitivity and 99.8% specificity, as required by the TPP for Onchocerciasis Elimination Mapping.
  • Demonstration that the Ov16/OVOC3261 biplex IgG4 test behaves at least as good with blood as with plasma/serum samples (notably a perceived weakness of the SD Ov16 RDT)
Diseases: Onchocerciasis

Rapid Diagnostic Test For Lymphatic Filariasis Surveillance : Prioritization of Antigen Candidates Complementary to Wb123

The overall goal of this research proposal is to prioritize the five novel Bancroftian antigen candidates with respect to their ease-of-use and practicability within the frame of a future Wb123/WbAgx biplex test, based on their biophysical properties, stability data and behavior in our lateral flow assay setup. Along with the concurrent biochemical/clinical validation by the Nutman group. This will allow an informed choice as to which candidate antigen(s) should be used for the biplex assay development.