How does the performance of the AP ELISA compare to the Ov16 SD ELISA, when conducted in a country lab?
Understanding areas of increased trachoma risk (hotspots) through the implementation of a post validation trachoma surveillance strategy
To determine if there is evidence of on-going or recent transmission in the “hotspot” communities of increased risk two years after they were identified during the pre-validation surveys (clinical, antibody and infection data).
ClearTrachoma: Evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas
The primary aim of this study is a first evaluation (384 samples) of the DjinniChip in ocular clinical samples in a trachoma-endemic region in-country, but initially in the controlled environment of a research laboratory setting. The second aim is to determine the DjinniChips resilience and usability by evaluating its performance with a concentration series of positive control swabs in various environmental conditions (hot, dry, dusty, humid).
Production of a New Dual Antigen Test Strip as a Tool to Support Epidemiologic Assessments of Onchocerciasis
How does the performance of the new Ov16/Ov3261 test strip compare to that of the SD Ov16 RDT and the SD Ov16 ELISA?
Towards sustainability of Schistosomiasis Control: improving health of lake shore communities and engaging civil society structures, educational and health facilities in the hyper-endemic area of Mwanza, Tanzania
Schistosomiasis is among the neglected tropical diseases which are highly endemic in Tanzania, especially along and on the Island of Lake Victoria, in northwestern region. After Nigeria, Tanzania is second country in sub-Saharan Africa for having the highest prevalence of schistosomiasis infection and it is estimated that 52% of approximately 50 million people are living with the disease. Current control strategies in Tanzania focus on mass drug administration (MDA) of Praziquantel (PZQ) mainly in school children. Despite of these efforts, the burden of disease remains high, showing local infection rates of up to 97% among school children. School- based MDA alone is unlikely to have a lasting effect on transmission. Awareness creation and engagement across sectors and of civil society (cooperatives, community councils) structures will help to achieve more sustainable results. The objective of this project is to engage affected communities and civil society structures representing risk population (cooperatives, beach management units) to create awareness through e.g. CHAST (children’s hygiene and sanitation training), participation in control activities and improved health seeking behaviors. Secondarily, the study aims to institutionalize measures for early diagnosis and treatment in health facilities of Nyamagana and Ilemela district, along the Lake Victoria, northwestern Tanzania.
Would the same programmatic decisions for Oncho Elimination Mapping be made based off of the Ov16 rapid diagnostic test results as compared to the Ov16 SD ELISA results?
To investigate the utility of an antibody test as a tool for surveillance during the elimination phase of trachoma programmes
To assess the programmatic feasibility of and determine the most appropriate age group and sample strategy for an onchocerciasis mapping survey for ivermectin-naïve areas.
Integrating use of point-of-care circulating cathodic antigen rapid diagnostic by community health workers during mass drug administration campaign to increase uptake of praziquantel treatment among adult populations in North-Western Tanzania
To assess if introducing point-of-care Circulating Cathodic Antigen rapid test to community health workers will increase access, compliance and coverage to treatment among adult individuals at Kome Island in North-Western Tanzania, an area on the Lake Victoria highly endemic for schistosomiasis
Development of a molecular diagnostic method for soil-transmitted helminthiases: Epidemiological implications for disease control
To improve STH detection by developing a reliable and easy to perform molecular diagnostic test for epidemiological surveillance and post-elimination monitoring of STH