Comparative-effectiveness study

Developing an appropriate model of care for lymphatic filariasis and leprosy patients who need MMDP services in Bihar State, India

What is the comparative effect of enhancing the existing MMDP services with or without community-based components in significantly reducing the burden of Acute Attacks (AA), Hydrocele, and Mental Health (MH) issues among people affected by LF?

Countries: India

Collaborative effort to address intestinal worms through education, medical care, health assessments, quizzes/contests in school

The effectiveness of motivating locals to address intestinal worms through education, medical care and health assessments.

Countries:

Understanding areas of increased trachoma risk (hotspots) through the implementation of a post validation trachoma surveillance strategy

To determine if there is evidence of on-going or recent transmission in the “hotspot” communities of increased risk two years after they were identified during the pre-validation surveys (clinical, antibody and infection data).

Countries: Ghana
Diseases: Trachoma

ClearTrachoma: Evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas

The primary aim of this study is a first evaluation (384 samples) of the DjinniChip in ocular clinical samples in a trachoma-endemic region in-country, but initially in the controlled environment of a research laboratory setting. The second aim is to determine the DjinniChips resilience and usability by evaluating its performance with a concentration series of positive control swabs in various environmental conditions (hot, dry, dusty, humid).

Countries: Tanzania
Diseases: Trachoma

Lymphatic Filariasis Positive-Case Follow-up After TAS 2 in Haiti

To identify the sampling strategy for positive case follow-up after TAS 2 and TAS 3 that optimizes the chances of correctly identifying evidence of ongoing transmission, while saving program resources.

Countries: Haiti

The Global Atlas of Podoconiosis

Through funding from the Wellcome Trust to develop a global atlas of podoconiosis. We aim to advance new knowledge on the geographical distribution and spatial epidemiology of the disease.

i. Conduct national cross-sectional surveys in selected countries to validate the environmental predictive model developed using the mapping data in Ethiopia.

ii. Create evidence consensus maps, develop risk maps and ground-truthing work and delineate the spatial distribution and geographical limits of podoconiosis globally.

iii. Estimate the global burden of podoconiosis by quantifying the number affected, the population at risk and DALYs attributable.

iv. Estimate how much it will cost to control or eliminate podoconiosis globally.

 

Countries: Ethiopia | Cameroon | Rwanda | Uganda | Burundi | India
Diseases: Podoconiosis

Studies of Gene Expression Pattern of Glutathione-S-Transferase (OvGST1) in the host and vector Simulium damnosum s.l.

To study the glutathione-S-transferase (OvGST1) gene expression pattern in the life cycle stages critical for the establishment of infection by Onchocerca volvulus.

Countries: Nigeria
Diseases: Onchocerciasis

Evaluation and Control of Cutaneous Leishmaniasis in KSA

Cutaneous Leishmaniasis (CL) is exclusively transmitted by the bite of a female sand fly. In collaboration with the Saudi Arabian Ministry of Health, we have developed a programme aiming to prevent and control CL in this country. The programme focuses, among other aspects, in developing a rapid diagnostic test based on the patient’s anti-alpha-Gal response, and in identifying markers for disease exposure. We recently found evidence that treatment efficacy against Old World CL varies with parasite species, geographical locations and the development of secondary infections. This has implications on the treatment of this debilitating disease. The severity of a leishmaniasis ulcer partly depends on the patient’s previous exposure to sand fly bites. This explains the increased protection against CL in individuals living in CL-endemic areas and supports development of potential vaccine models based on sand fly salivary proteins. Furthermore, Old World CL patients produce high levels of anti-Gal antibodies (i.e. recognise terminal alpha-galactosyl epitopes). This discovery is currently being exploited for the making of rapid diagnostic tools and a potential protective glycovaccine model against CL. We hope that these tools can soon be applied in other CL-endemic countries, including refugee settings.

Countries: Saudi Arabia
Diseases: Leishmaniasis

TUMIKIA project

The TUMIKIA Project aims to determine whether combining school- and community-based deworming is more effective at controling and eliminating soil-transmitted helminths (STH or intestinal worms) in Kenya than school-based deworming alone. 

The two-year trial will provide the drug albendazole to all residents from 150 communities in Kwale County, Kenya. There are three study groups:

  1. Base: annual school-based deworming (ages 2-14)
  2. Increased coverage: annual school- and community-based deworming (ages 2-99)
  3. Increased coverage and frequency: bi-annual school- and community-based deworming (ages 2-99)

TUMIKIA stands for 'Tuangamize Minyoo Kenya Imarisha Afya,' which means “eradicate worms in Kenya to improve health,” in Swahili. 

Download the TUMIKIA Research Brief [pdf]

Countries: Kenya

Economic analysis in SCORE projects

Economic evaluation of SCORE projects with priority given to elimination studies

 

Countries: Tanzania | Cote d'Ivoire
Diseases: Schistosomiasis

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