Clinical trial

Enhanced self-care protocol for case management of severe lymphoedema

This study aims to determine if the addition of lymphatic stimulating activities to community-based home-care for lymphoedema can improve outcomes for people affecetd by moderate to late stage disease. 

Countries: Bangladesh | Ethiopia

Doxycycline for Clinical Management of Filarial Lymphedema (Mali)

Determine whether doxycycline treatment daily for 6 weeks improves clinical outcomes (swelling, acute attacks) in lymphedema patients.

Countries: Mali

Integrating use of point-of-care circulating cathodic antigen rapid diagnostic by community health workers during mass drug administration campaign to increase uptake of praziquantel treatment among adult populations in North-Western Tanzania

To assess if introducing point-of-care Circulating Cathodic Antigen rapid test to community health workers will increase access, compliance and coverage to treatment among adult individuals at Kome Island in North-Western Tanzania, an area on the Lake Victoria highly endemic for schistosomiasis

Countries: Tanzania
Diseases: Schistosomiasis

Long term outcome of the two most commonly used surgical procedures to treat trachomatous trichiasis (TT): PLTR vs BLTR

Ascertain whether the difference in outcome (measured in rate of post-operative trachomatous trichiasis, or TT), between the posterior lamellar tarsal rotation (PLTR) and bilamellar tarsal rotation (BLTR) is sustained at four years or whether they give different results from what has been found at 1 year.

Countries: Ethiopia
Diseases: Trachoma

Doxycycline for Clinical Management of Filarial Lymphedema (Sri Lanka)

Determine whether doxycycline treatment daily for 6 weeks improves clinical outcomes (swelling, acute attacks) in lymphedema patients.

Countries: Sri Lanka

A-WOL Macrofilaricidal Drug Discovery

Deliver at least one novel pre-clinical candidate capable of delivering a macrofilaricide treatment for onchocerciasis (and lymphatic filariasis) within a seven-day treatment period or less.

Countries:

Optimizing and implementing A·WOL macrofilaricidal drugs and regimes

Establish the best registered drug for deployment as a macrofilaricide alone and/or in combination with standard anti-filarial drugs.

Countries:

AWOL Discovery Supplemental Award

Late lead optimisation

Countries:

Global Health Innovative Technology Fund (GHIT): 2014-2016 Anti-Wolbachia lead optimisation

Establish the most promising template for final lead optimization from a screen of >10000 compounds from the BioFocus library which revealed compounds with very good anti-Wolbachia activity.

Countries:

Doxycycline for Clinical Management of Filarial Lymphedema (India)

Determine whether doxycycline treatment daily for 6 weeks improves clinical outcomes (swelling, acute attacks) in lymphedema patients.

Countries: India

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