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To compare antigenemia results by ICT and FTS RDT, antibody responses to Wb123 and Ov 16 by ELISA , and Wb123/Ov16 Biplex RDT on LF sentinel sites.

To compare TAS-STH vs. a standalone STH survey in 5 schools surveying 250 kids. TAS-STH Community study will have 6-7 year olds while the STH survey focuses on 10-14 year olds.

Define improved strategies, support development of WHO recommendations, and ensure communication to struggling countries; Acceleration of global elimination efforts to achieve 2020 goals

Assess Wb123 antibody responses in communities where LF transmission was interrupted without MDA.

To compare skin snip microfiladermia with antibody responses against Ov16 antigen in general population in epidemiological assessments post CDTi.

CCA Protocol: To know the sensitivity and specificity of POC CCA in the detection of urinary schistosomiasis, as compared to traditional diagnostic tools.

Test STH-TAS,Understand the age prevalence of LF Antibody in different setting.

SCORE Data Collection on Mobile Devises

Snail Control follow-up study of P. clarkii 20 years later

Human Diagnostics Tool Development (CAA diagnostic tool)

POC/CCA screening/mapping tool initial Studies

Screening Tool POC/CCA: PCR comparative studies

POC/CCA tool ongoing studies: Use of testing standards; reader differences; ‘Trace’ result analyses

Cost Studies in SCORE Gaining and Sustaining

Mapping of schistosomiasis (Sm)

Develop genetic markers for S. haematobium

Schistosome Population Genetics in Gaining Control Studies in Niger (Sh) and Tanzania (Sm)

Part of gaining control studies

Gaining Control: >25% Prevalence MDA strategies; and subtle morbidity of Cohort; Population genetics, and snail monitoring

Sustaining / Gaining Control with Single versus Double Treatment; and Population genetics, snail monitoring

MDA strategies: Sustaining control at 10 – 24% prevalence

(1) Is it possible to eliminate schistosomiasis as a public health problem on Unguja in three years and to interrupt transmission in five years? (2) Is it possible to control schistosomiasis throughout Pemba (prevalence <10%) in three years and to eliminate it as a public health problem in five years? (3) What are the costs, successful strategies, barriers, etc. associated with three different interventions (MDA, vector control, and behavior change)?

Randomized clinical trail comparing treatment with Albendazole and Ivermectin to Ivermectin alone for Onchocerciasis.

Randomized Clinical Trial of Albendazole vs Ivermectin+Albendazole for lymphatic filariasis treatment and elimination.

Randomized Clinical Trial comparing triple triple therapy of DEC/Alb/Iver vs. DEC/Alb alone

Comparison of 2X vs. 1X per year MDA on Brugia with MDA of DEC/Alb , plus STH evaluation

Community MDA with 2X Alb alone for W. bancrofti in areas co-endemic for L. loa, plus STH evaluation

Binax Now Filariasis Test vs. Alere Filariasis Test Strip Comparison

Comparison of 2X vs. 1X per year MDA on W. bancrofti with MDA of IVM/Alb, plus STH evaluation (and Schistosoma in Foya only)

Comparison of 2X vs. 1X per year MDA, W. bancrofti with MDA of DEC/Alb, plus STH evaluation