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Operational research to develop an M&E strategy to guide triple drug stopping decisions for lymphatic filariasis in Kenya

What is the indicator(s) and accompanying M&E strategy that enables country programs to determine when the risk of ongoing transmission of LF has been reduced so that IDA can be stopped with little risk of resurgence of transmission?

Countries: Kenya

Processing Ov16 ELISA for Oncho Elimination Mapping

Would the same programmatic decisions for Oncho Elimination Mapping be made based off of the Ov16 rapid diagnostic test results as compared to the Ov16 SD ELISA results?

Countries: Kenya | Malawi | Burundi
Diseases: Onchocerciasis

Lymphatic Filariasis Positive-Case Follow-up After TAS 2 in Haiti

To identify the sampling strategy for positive case follow-up after TAS 2 and TAS 3 that optimizes the chances of correctly identifying evidence of ongoing transmission, while saving program resources.

Countries: Haiti

Improving Access to Mass Drug Administration for Lymphatic Filariasis Elimination using a Participatory Approach among Communities of Coastal Kenya

To assess the socio-economic factors contributing to low access to MDA, to identify the existing health services opportunities and other outlets specific to various socio-economic groups that could be used for improving access to MDA, and to develop feasible field-applicable strategies that can be used to reach groups with consistently low access to MDA.

Countries: Kenya

Development of Tools to Re-Orient Social Mobilization Strategies to Close the MDA Coverage-Compliance Gap

To improve compliance and reduce the coverage-compliance gap in mass drug administration through enhanced and tailored social mobilization.

Countries: Indonesia

Equitable access to Mass Drug Administration for trachoma elimination: an ethnographic study to understand factors associated with low coverage in Kenya and Tanzania

Main objectives are firstly to identify and understand better the factors behind low and unequal MDA coverage and compliance in trachoma endemic areas in Tanzania and Kenya with nomadic populations, secondly to prioritize factors in terms of amenability to intervention. The researcher will then use the evidence generated to design specific interventions that could improve the reach and impact of campaigns of Zithromax MDA in both countries.  While there are contextual differences between nomadic societies throughout Africa, research among the Masai in Tanzania and Kenya should inform programme services in other settings with nomadic populations. Particular attention will be given to gender-sensitivity; that is, interventions that will improve access and use by women as well as men.

Countries: Kenya | Tanzania
Diseases: Trachoma

Operational research to develop an M&E strategy to guide triple drug stopping decisions for lymphatic filariasis in Samoa

What is the indicator(s) and accompanying M&E strategy that enables country programs to determine when the risk of ongoing transmission of LF has been reduced so that IDA can be stopped with little risk of resurgence of transmission?

Countries: Samoa

Development of a geostatistical mapping tool to improve decision-making for Loa loa and LF

Can serological markers for NTDs (particularly Loa loa and Lymphatic filariasis) be incorporated into geostatistical maps and used to guide program decisions around treatment and surveillance?

Does infection data add evidence to understanding of trachoma prevalence in low endemic areas?

To investigate the utility of an antibody test as a tool for surveillance during the elimination phase of trachoma programmes

Countries: Tanzania
Diseases: Trachoma

District Mapping Onchocerciasis and Lymphatic Filariasis in Ethiopia

To assess the programmatic feasibility of and determine the most appropriate age group and sampling strategy for an oncho mapping survey for ivermectin-naïve areas

Countries: Ethiopia

District Mapping Onchocerciasis and Lymphatic Filariasis in Kenya

To assess the programmatic feasibility of and determine the most appropriate age group and sample strategy for an onchocerciasis mapping survey for ivermectin-naïve areas.

Countries: Kenya

Lymphatic filariasis positive-case follow-up after TAS 2 or TAS 3 in Philippines

To identify the sampling strategy for positive case follow-up after TAS 2 and TAS 3 that optimizes the chances of correctly identifying evidence of ongoing transmission, while saving program resources.

Countries: Philippines

District Elimination Mapping of Onchocerciasis in Burundi

To assess Onchocerciasis transmission in the districts previously called hypo-endemic or of unknown endemicity using a new more sensitive diagnostic and sampling strategy

Countries: Burundi | Burundi | Burundi

Sustaining the Gains of NTD elimination programs through focused support of community drug distributors

To sustain the gains of active community drug distributors (CDDs) by enhancing their performance through intervention at the individual, community and primary health care center levels to reach NTD elimination and control goals.

Countries: Uganda | Cote d'Ivoire

Doxycycline for Clinical Management of Filarial Lymphedema (Mali)

Determine whether doxycycline treatment daily for 6 weeks improves clinical outcomes (swelling, acute attacks) in lymphedema patients.

Countries: Mali

Integrating use of point-of-care circulating cathodic antigen rapid diagnostic by community health workers during mass drug administration campaign to increase uptake of praziquantel treatment among adult populations in North-Western Tanzania

To assess if introducing point-of-care Circulating Cathodic Antigen rapid test to community health workers will increase access, compliance and coverage to treatment among adult individuals at Kome Island in North-Western Tanzania, an area on the Lake Victoria highly endemic for schistosomiasis

Countries: Tanzania
Diseases: Schistosomiasis

Does infection data add anything to our understanding of trachoma prevalence in low endemic areas?

To investigate prevalence of ocular chlamydial infection and associated risk factors in children aged 1-9 year in Manyoni district

Countries: Tanzania
Diseases: Trachoma

Development of a molecular diagnostic method for soil-transmitted helminthiases: Epidemiological implications for disease control

To improve STH detection by developing a reliable and easy to perform molecular diagnostic test for epidemiological surveillance and post-elimination monitoring of STH

Countries: Cameroon

Demand creation and services uptake push for onchocerciasis control in Cross River State, Nigeria

To increase onchocerciasis treatment coverage and to optimize service delivery through community mobilization, disease sensitization, training and strengthening of community health extension workers (CHEW), and community control advocates

Countries: Nigeria
Diseases: Onchocerciasis

Monitoring migrant groups as a post-treatment surveillance approach to contain the potential risk of lymphatic filaraisis re-emergence after stopping mass drug administration in Togo

In March 2016, the Republic of Togo submitted an application for validation of the elimination of LF as a public health problem. However, healthcare facility managers in some health regions – especially in the Savanes Region, have reported the presence of migrant groups from neighboring countries which are still endemic to LF – i.e. Ghana, Burkina Faso, Nigeria. Migrants arrive and reside temporarily but recurrently in some localities of these regions. They constitute hotspots that can be source of resurgence, mainly because the nationwide passive surveillance has been stopped in 2016. 

In order to track all population movements that constitute a potential risk to the Republic of Togo, the country proposes to set up a strategy for the identification of these groups, with the contribution of Neglected Tropical Disease (NTD) Focal Points, followed by the research of potential parasite carriers. Isolated cases discovered will be investigated in order to track all imported W. bancrofti. They will be treated, but if an effective hotspot is discovered, rounds of Albendazole and Ivermectin MDA will be implemented a follow up of infected individuals will be maintained. 

The purpose of this study is to contribute maintaining the end of LF transmission across the country.

Countries: Togo

Investigation of possible ongoing Schistosoma hybridization in Nigeria and implications for response to treatment

To investigate the presence and epidemiology of Schistosoma hybrids in Nigeria. The acquisition of new genes through hybridization may generate new phenotypes that might differ in virulence, drug resistance, pathology, and host use, ultimately leading to the emergence of new diseases. Hybrids can develop into a new emerging pathogen, necessitating new control strategies in zones where both parental species overlap, an intense and rapid control response is required to minimize further spread of the hybrid and possible escalation of human schistosomiasis.

Countries: Nigeria
Diseases: Schistosomiasis

Field testing the use of 3D photographs of trachomatous trichiasis to train trachoma field graders

To evaluate 3D photographs of trachomatous trichiasis (TT) in the training and assessment of trachoma graders.

Countries: Ethiopia
Diseases: Trachoma

Long term outcome of the two most commonly used surgical procedures to treat trachomatous trichiasis (TT): PLTR vs BLTR

Ascertain whether the difference in outcome (measured in rate of post-operative trachomatous trichiasis, or TT), between the posterior lamellar tarsal rotation (PLTR) and bilamellar tarsal rotation (BLTR) is sustained at four years or whether they give different results from what has been found at 1 year.

Countries: Ethiopia
Diseases: Trachoma

Quality and quantity of post-epilation trichiatic lashes: a cohort study

To understand the nature (quality and quantity) of post epilation lashes and their visual significance in unoperated minor trachomatous trichiasis (TT) cases and case with post-operative trichiasis

Countries: Ethiopia
Diseases: Trachoma

District Mapping Onchocerciasis in Malawi

To assess the programmatic feasibility of and determine the most appropriate age group and sampling strategy for an oncho mapping survey for ivermectin-naïve areas

Countries: Malawi
Diseases: Onchocerciasis

Antibody Responses to Chlamydia trachomatis Antigens in Trachoma-Endemic Zones of Ethiopia

To analyze the relationships between the currently used indicator for impact assessments - prevalence of the clincial sign TF - and the prevalence of infection and antibody among 1-9 year old children in hyperendemic districts prior to mass drug administration

Countries: Ethiopia
Diseases: Trachoma

Doxycycline for Clinical Management of Filarial Lymphedema (Sri Lanka)

Determine whether doxycycline treatment daily for 6 weeks improves clinical outcomes (swelling, acute attacks) in lymphedema patients.

Countries: Sri Lanka

Determining end markers for stopping MDA for Trachoma in Malawi

Currently MDA is stopped when TF in children aged 1-9 years is below 5%. However, the relationship between TF, presence of infection and antibody has not been studied in a sufficient number of settings to enable predictions of outcome to be confidently made based on baseline prevalence, intervention coverage, and the prevalence of disease and infection at the time of impact survey. There are several districts in Malawi with TF prevalence between 5 and 9.9% which are eligible for one year of interventions, including a single round of MDA. This study will add important data to be used to model outcomes of interventions conducted by trachoma elimination programs, and in particular, help develop operational guidelines for stopping MDA.

Countries: Malawi | Malawi | Malawi
Diseases: Trachoma

Testing New RDT Formats to Improve Wb123 Test Sensitivity

To test alternative rapid diagnostic test (RDT) formats for the Wb123 rapid test. In field trials, the current test format was less sensitive that FTS in post-MDA settings whereas alternative Wb123 test formats (ELISA, multiplex) were more sensitive. Our group uses new detection systems, based on nanoshells, to improve RDT performance. 

District Mapping Onchocerciasis, Lymphatic Filariasis, and Loiasis in Gabon

To define a cost-effective strategy to map Ivermectin-naïve districts for Onchocerciasis, Lymphatic Filariasis, and Loiasis in the context of elimination of these NTDs

Countries: Gabon | Gabon | Gabon

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