Welcome to NTD ConnectOR, formerly known as the Operational Research (OR) Inventory. This resource serves as a hub for researchers, funders and program implementers involved in OR.
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Primary
1. Can the O-150 LAMP assay be established on whole blood? 2. Can the O-150 qPCR methodology be adapted for human sampling?
Secondary
1. How does the performance of the O-150 LAMP compare to the O-150 qPCR assay?
2. What threshold be used to define positive vs negative results for both assays?
3. Can deep sequencing reveal over potential biomarkers for further investigation?
The overall goal of this research proposal is to prioritize the five novel Bancroftian antigen candidates with respect to their ease-of-use and practicability within the frame of a future Wb123/WbAgx biplex test, based on their biophysical properties, stability data and behavior in our lateral flow assay setup. Along with the concurrent biochemical/clinical validation by the Nutman group. This will allow an informed choice as to which candidate antigen(s) should be used for the biplex assay development.