Projects

TAS Strengthening in Haiti - Lab and Xenomonitoring (Part II)

1) To analyze the ELISA (Wb123) results from the field sampling
2) To conduct the mosquito field collection
3) To analyze the mosquito samples using PCR

Countries: Haiti

Lab Component - TAS Strengthening in Tanzania

Primary Objective: To test the 4,500 samples collected as part of the TAS Strengthening Study in Tanzania for Wb123 and Ov16 antibodies using ELISA.

Secondary Objective: To build capacity at the Tanga laboratory so that it can serve as a regional lab for future specimen processing.

The TAS Strengthening Study in Tanzania (101G) is designed to assess additional indicators that may be added to the current TAS platform in order to strengthen the resulting stopping or surveillance decisions. The ELISA results will be merged with the antigen and demographic data, and ultimately with the xenomonitoring data.  A comprehensive analysis will be conducted to understand the correlation between antigen and antibody in adults and children with the mosquito data.  A spatial analysis looking at microfoci of infection will also be conducted. The ELISA results will feed into a larger multi-country analysis.  The results are expected to help inform WHO guidance on stopping and surveillance for LF. 

Countries: Tanzania

Integrated Mapping of Onchocerciasis, Lymphatic Filariasis, and Loiasis in Cameroon

To pilot a strategy for mapping and treating Onchocerciasis and Lymphatic Filariasis in Loa loa co-endemic areas.

Countries: Cameroon

Field-testing a Lateral Flow Assay for anti-Chlamydial Antibody Responses

To field-test the Pgp3 lateral flow assay to compare data obtained in the field on the rapid test to that from DBS collected from the same individual tested on the Pgp3 multiplex bead array.

Countries: Tanzania
Diseases: Trachoma

TAS Strengthening in Tanzania

To evaluate strategies to improve the sensitivity of the TAS for detecting evidence of recent lymphatic filariasis transmission in an evaluation unit (EU). Both xenomonitoring and the new Wb123 RDT will be evaluated through this research.

Countries: Tanzania

TAS Strengthening in Haiti

From this study we hope to better understand whether MDA can be safely discontinued in EUs with ‘high TAS passing’ results, such as found in Limbé.

Countries: Haiti

TAS Strengthening in American Samoa

To strengthen the existing TAS platform so that the programs can be more confident with their stopping and surveillance decisions. 

To evaluate strategies to improve the sensitivity of the TAS for detecting evidence of recent lymphatic filariasis transmission in an evaluation unit (EU). Both xenomonitoring and the new Wb123 RDT will be evaluated through this research. 

Countries: American Samoa

Single vs. multiple treatments of praziquantel in intestinal African schistosomiasis: a randomized, double-blind, placebo controlled trial investigation using new diagnostic tools

Rigorous assessment of the efficacy of (multiple) doses with Praziquantel in the treatment of S. mansoni infections using standard and novel highly sensitive diagnostic tools.

Countries: Cote d'Ivoire
Diseases: Schistosomiasis

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