MDA
Determination of the prevalence of LF infection in districts not included in LF control activities and of the basis for integrated implementation of LF - onchocerciasis elimination strategies in potentially co-endemic areas
Field validation of the diagnostic performance of the Wb123/Ov16 biplex rapid diagnostic test and Wb123 ELISA, compared to the filariasis test strip (FTS) in a setting initially found to be non-endemic for lymphatic filariasis, in which clinical cases have been identified.
IDA Acceptability Study (Fiji)
Assess the overall acceptability of the 3-drug treatment in the community as compared to the 2-drug treatment
IDA Acceptability Study (India)
Assess the overall acceptability of the 3-drug treatment in the community as compared to the 2-drug treatment
TUMIKIA project
The TUMIKIA Project aims to determine whether combining school- and community-based deworming is more effective at controling and eliminating soil-transmitted helminths (STH or intestinal worms) in Kenya than school-based deworming alone.
The two-year trial will provide the drug albendazole to all residents from 150 communities in Kwale County, Kenya. There are three study groups:
- Base: annual school-based deworming (ages 2-14)
- Increased coverage: annual school- and community-based deworming (ages 2-99)
- Increased coverage and frequency: bi-annual school- and community-based deworming (ages 2-99)
TUMIKIA stands for 'Tuangamize Minyoo Kenya Imarisha Afya,' which means “eradicate worms in Kenya to improve health,” in Swahili.
Understanding the best uses of the Supervisor's Coverage Tool (SCT) for monitoring school-based distributions
- To use the Supervisor's Coverage Tool (SCT) to monitor school-based deworming;
- To determine the feasibility of utilizing the Lot Quality Assurance Sampling (LQAS) methodology in a school-based SCT; and
- To apply a checklist in schools to elicit information about the performance of the MDA.
Interventions in Persistent Hot-Spots in Kenya
Will providing enhanced MDA at the community level while achieving treatment coverage of 75% or greater in children (5-17) and adults substantially decrease S. mansoni infection in previously identified persistent hot-spot communities?
Xenomonitoring Surveillance
Is molecular detection of schistosome infection (patent and pre-patent) in snails a useful tool for program managers as prevalence and intensity of infection in people approaches very low levels?
Interventions in Persistent Hot-Spots in Tanzania
How do villages which do not show substantial decreases in the prevalence of schistosomiasis despite repeated, high coverage mass drug administration (persistent hot-spot villages) differ from villages which show substantial decrease in prevalence across various factors (declining prevalence villages)?
Triple Drug Therapy for LF
Comparison of safety profile and acceptability between triple drug therapy (IVM,DEC,ALB) and standard two-drug therapy (DEC, ALB), plus STH evaluation.