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Adding Antibody Testing to Mini-TAS

To compare results from Brugia Rapid tests (in 3 districts) and FTS (in 2 districts) with Wb123 rapid tests and Wb123 and Bm14 ELISA testing.

Countries: Viet Nam

District Mapping Onchocerciasis, Lymphatic Filariasis, and Loiasis in Nigeria

To define a cost-effective and accurate method to map ivermectin-naïve districts for Onchocerciasis, Lymphatic Filariasis and Loiasis and identify districts eligible for safe treatment with ivermectin MDA.

Countries: Nigeria

Integrated Transmission Assessment Surveys (iTAS) and Onchocerciasis evaluation in areas of Co-Endemicity for both infections in Tanzania

To determine the validity and programmatic feasibility of an integrated transmission assessment survey (F-TAS), to be used to simultaneously assess Onchocerciasis (Oncho) and Lymphatic Filariasis (LF) prevalence in areas co-endemic for the two infections that have completed the recommended treatment for one or both infections.

Countries: Tanzania

STH Diagnostic Comparison: PCR vs. Kato-Katz, Uganda

To determine if a standardized multi-parallel-PCR assay is a more sensitive diagnostic tool for detecting Hookworm (Ancylostoma duodenale and Necator americanus), Trichuris trichiura, Ascaris lumbricoides, Strongyloides stercoralis, and Schistosoma mansoni prevalence compared to the Kato-Katz stool test.

Countries: Cameroon

The Impact of an Enhanced Antibiotic Treatment Regimen on Trachoma in Amhara, Ethiopia

What are the differences at 1 year post-baseline in the prevalence of trachoma and Ct infection in villages randomized to an enhanced antibiotic treatment regimen characterized by a routine community-wide MDA followed by two rounds of treatment targeted to children 6 months to 9 years in quick succession (1-2 weeks apart) compared to villages randomized to annual standard-of-care community-wide MDA?

Countries: Ethiopia
Diseases: Trachoma

Life on the edge: tackling Africa HAT on the edge of wilderness areas

LSTM |

Our proposal will study the interaction between humans, livestock and wildlife and the role of this transition zone in the transmission of trypanosomes at the edge of the Serengeti National Park in Tanzania. To assess whether focussed control of tsetse is effective, we will develop mathematical models of the transmission of trypanosomes in the transition zone from wildlife-dominated areas on the park boundaries through to livestock-dominated areas outside the parks. The models will enable us to predict the likely extent, duration and cost of interventions required to interrupt the transmission of trypanosomes at boundary areas. 

Countries: Tanzania

Molecular Characterisation of Anopheles gambiae Heme Oxygenase

LSTM |

Understanding how mosquitoes survive a blood meal

Countries:

Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake venom pathology and antivenom efficacy

LSTM |

Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake venom pathology and antivenom efficacy

Countries:
Diseases: Snakebite

Mechanism to reverse the neglect of snakebite victims

LSTM |

To understand the mechanism to reverse the neglect of snakebite victim

Countries:
Diseases: Snakebite

Use of tiny targets to control HAT in Chad

LSTM |

Explore the use of tiny targets to control Human African Trypanosomiasis (HAT) in Chad

Countries: Chad

Integrated HAT control - a model district in DRC

LSTM |

Determine the effectiveness of integrated control of Human African Trypanosomiasis (HAT) in a model district in DRC

Countries: Dem. Rep. of Congo

Effectiveness of tiny target technology in controlling tsetse vectors for HAT

LSTM |

To determine the effectiveness of tiny target technology in controlling tsetse vectors for Human African Trypanomiasis

Countries:

Lead on social science

LSTM |

Determine the best health systems approaches for:

1. Improved planning and delivery of integrated programmes; 
2. Increased and sustained access to NTD drugs; 
3. Harmonised inter-sectoral approach; and 
4. Strong and generalisable evidence base for integrated elimination and control of NTDs.

 

Countries:

Molecular tools for insecticide resistance diagnosis in phlebotomine sandflies for sustainable leishmaniasis control and elimination programme

LSTM |

Developing new diagnostic tools to monitor insecticide resistance in sandflies in India

Countries: India
Diseases: Leishmaniasis

Improving the impact of IRS for Visceral Leishmaniasis with enabling integrated decision support systems

LSTM |

Improving effectiveness of vector control against Visceral Leishmaniasis

Countries:
Diseases: Leishmaniasis

Insecticide resistance in dengue vectors, Jeddah

LSTM |

Defining the insecticide resistance status of dengue vectors in Jeddah and Makkah; essential prerequisite to developing an effective response in the event of an outbreak in these important sites.

Countries: Saudi Arabia

Mapping schistosomiasis and soil-transmitted helminthiasis in Namibia

LSTM |

Assessing treatment needs for school-aged children and assisting Ministry of Health to develop an effective control programme

Countries: Namibia

Drug formaulation for pre-school children

LSTM |

Understanding the basic pharmacology of praziquantel tailored to paediatric setting and developing a treatment access plan for this age class

Countries:

COUNTDOWN Calling

LSTM |

Helping increase and sustain the scale-up of preventive chemotherapy campaigns in West and Central Africa

Countries:

A-WOL Macrofilaricidal Drug Discovery

LSTM |

Deliver at least one novel pre-clinical candidate capable of delivering a macrofilaricide treatment for onchocerciasis (and lymphatic filariasis) within a seven-day treatment period or less.

Countries:

Optimizing and implementing A·WOL macrofilaricidal drugs and regimes

LSTM |

Establish the best registered drug for deployment as a macrofilaricide alone and/or in combination with standard anti-filarial drugs.

Countries:

AWOL Discovery Supplemental Award

LSTM |

Late lead optimisation

Countries:

Global Health Innovative Technology Fund (GHIT): 2014-2016 Anti-Wolbachia lead optimisation

LSTM |

Establish the most promising template for final lead optimization from a screen of >10000 compounds from the BioFocus library which revealed compounds with very good anti-Wolbachia activity.

Countries:

Strengthen the capacity of the 5 African university departments hosting the MCDC programme

LSTM |

To strengthen the capacity of the 5 African university departments hosting the Malaria Capacity Development Consortium (MCDC) programme

Countries: Senegal | Mali | Gambia | Ghana

Studies on the glycosylation of metacyclic trypanosomes

LSTM |

The development of Trypanosoma brucei within the tsetse vector is accompanied by the expression of several stage-specific families of GPI-anchored surface glycoproteins. We recently discovered that saliva from T.brucei-infected tsetse flies is enriched with Brucei Alanine-Rich Proteins (BARP), VSG and a novel family of GPI-anchored surface glycoproteins. The latter are phylogenetically grouped within the Clade IV of family 50 of trypanosome surface proteins and are encoded by five paralogs, whose products are over 90% identical in sequence. Immunofluorescence and transcript analysis showed that Clade IV proteins are expressed on the surface of metacyclic trypanosomes and also on epimastigotes and pre-metacyclic forms although in lower abundance. This expression pattern opposes that of BARP, which is highly expressed in the epimastigote stage and diminishes during differentiation to metacyclics. Because Clade IV proteins are almost identical in sequence and are heavily expressed in the metacyclic stage, we named them Metacyclic Invariant.

Countries:
Diseases: Leishmaniasis

Novel immuno-proteomic strategies to develop a polyspecific, non-cold chain liquid snake antivenom with unparalleled sub-Saharan African efficacy

LSTM |

To develop a polyspecific, non-cold chain liquid snake antivenom with unparalleled sub-Saharan African efficacy

Countries:
Diseases: Snakebite

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