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Field Validation of Wb123 monoplex, Haiti

To compare the performance of antigen (FTS) and antibody (Wb123 monoplex) tools in programmatic settings (TAS).

Countries: Haiti

IDA Acceptability Study

Assess the overall acceptability of the 3-drug treatment in the community as compared to the 2-drug treatment

Countries: India

TAS Strengthening in American Samoa

To evaluate strategies to improve the sensitivity of the TAS for detecting evidence of recent lymphatic filariasis transmission in an evaluation unit (EU). The TAS Strengthening Study in American Samoa is designed to assess additional indicators that may be added to the current TAS platform in order to strengthen the resulting stopping or surveillance decisions. A comprehensive analysis will be conducted to understand the correlation between antigen and antibody in adults and children with the mosquito data. A spatial analysis looking at microfoci of infection will also be conducted.  Xenomonitoring work to assess Aedes mosquitoes is underway.

The results from this study will be combined into a multi-country analysis and are expected to help inform WHO guidance on stopping and surveillance for LF. 

Countries: American Samoa

District-Level Integrated Mapping of Onchocerciasis, Lymphatic Filariasis, and Loiasis in Nigeria

  • To define a cost-effective and accurate method to map ivermectin-naïve districts for Onchocerciasis, Lymphatic Filariasis and Loiasis and identify districts eligible for safe treatment with ivermectin MDA.
  • To validate a statistical model of Loiasis prevalence and intensity by comparing the model results to data from a prevalence assessment.
Countries: Nigeria

TUMIKIA project

The TUMIKIA Project aims to determine whether combining school- and community-based deworming is more effective at controling and eliminating soil-transmitted helminths (STH or intestinal worms) in Kenya than school-based deworming alone. 

The two-year trial will provide the drug albendazole to all residents from 150 communities in Kwale County, Kenya. There are three study groups:

  1. Base: annual school-based deworming (ages 2-14)
  2. Increased coverage: annual school- and community-based deworming (ages 2-99)
  3. Increased coverage and frequency: bi-annual school- and community-based deworming (ages 2-99)

TUMIKIA stands for 'Tuangamize Minyoo Kenya Imarisha Afya,' which means “eradicate worms in Kenya to improve health,” in Swahili. 

Download the TUMIKIA Research Brief [pdf]

Countries: Kenya

Evaluation of alternative indicators for stopping trachoma mass drug administration

To assess the relationships between the prevalence of the clinical sign TF compared to prevalence of infection and antibody in Chikwawa and Mchinji districts

Countries: Malawi
Diseases: Trachoma

Trachoma in the Western Pacific

Determine whether current or historic C. trachomatis (Ct) infection can be detected, and whether it is associated with clinical signs of ‘trachomatous inflammation – follicular’ (TF) in Vanuatu and Kiribati

Determine the utility of infection testing as a tool for operational surveillance and impact assessment in trachoma-endemic environments.

Countries: Kiribati | Vanuatu
Diseases: Trachoma

Determining end markers for stopping MDA for Trachoma in Malawi

To establish relationship between clinical signs of trachoma, presence of infection, and anti-trachoma antibody in children aged 1-9 years

Countries: Malawi
Diseases: Trachoma

Filariases Transmission Assessment Survey (F-TAS) in Burkina Faso

To study the feasibility of LF and Oncho (Filariases) integrated transmission assessment survey (F-TAS)  according to both LF and Onchocerciasis  WHO elimination guidelines

Countries: Burkina Faso

Filariases Transmission Assessment Survey (F-TAS) in Nigeria

To study the feasibility of LF and Oncho (Filariases) integrated transmission assessment survey (F-TAS) according to both LF and Onchocerciasis WHO elimination guidelines

Countries: Nigeria

TAS Strengthening in the Philippines

To determine if there is evidence of ongoing transmission of lymphatic filariasis in Mindoro Oriental, following a TAS 2 failure.

Countries: Philippines

Bangladesh STH Diagnostic Comparison: PCR vs. Kato-Katz

To determine if a standardized multi-parallel-PCR assay is a more sensitive diagnostic tool for detecting Hookworm, Trichuris trichiura, Ascaris lumbricoides, and Strongyloides prevalence compared to the Kato-Katz stool test.

Countries: Bangladesh

Understanding the best uses of the Supervisor's Coverage Tool (SCT) for monitoring school-based distributions

  • To use the Supervisor's Coverage Tool (SCT) to monitor school-based deworming;
  • To determine the feasibility of utilizing the Lot Quality Assurance Sampling (LQAS) methodology in a school-based SCT; and 
  • To apply a checklist in schools to elicit information about the performance of the MDA.
Countries: Kenya

Laboratory analysis of Ov16 ELISA and Skin snip PCR to support surveillance activities in National programs. Multi-country comparison of diagnostic tools to detect Onchocerca volvulus.

To compare the performance of the diagnostic tools currently available for O. volvulus in terms of their relative sensitivity, species-specificity and practical use by countries.  Comparison of the utility of these tools for mapping and surveillance in settings with different levels of endemicity for onchocerciasis (Oncho), lymphatic filariasis (LF) and/or loiasis.

Countries: Burkina Faso
Diseases: Onchocerciasis

Integrated Mapping of Onchocerciasis, Lymphatic Filariasis, and Loiasis in Cameroon

To pilot a strategy for mapping and treating Onchocerciasis and Lymphatic Filariasis in Loa loa co-endemic areas.

Countries: Cameroon

TAS Strengthening in Haiti - Lab and Xenomonitoring (Part II)

1) To analyze the ELISA (Wb123) results from the field sampling
2) To conduct the mosquito field collection
3) To analyze the mosquito samples using PCR

Countries: Haiti

Field-testing a Lateral Flow Assay for anti-Chlamydial Antibody Responses

To field-test the Pgp3 lateral flow assay to compare data obtained in the field on the rapid test to that from DBS collected from the same individual tested on the Pgp3 multiplex bead array.

Countries: Tanzania
Diseases: Trachoma

Podoconiosis, trachomatous trichiasis and cataract in northern Ethiopia: a comparative cross-sectional study

Is there an association between podoconiosis and two common eye diseases; cataract and trachomatous trichiasis?

Countries:
Diseases: Podoconiosis | Trachoma

BURDEN ASSESSMENT OF PODOCONIOSIS IN WAYU TUKA WOREDA, EAST WOLLEGA ZONE, WESTERN ETHIOPIA

What is the burden of podoconiosis lymphoedema and acute attack in Western Ethiopia?

 

Countries:
Diseases: Podoconiosis

Interventions in Persistent Hot-Spots in Kenya

Will providing enhanced MDA at the community level while achieving treatment coverage of 75% or greater in children (5-17) and adults substantially decrease S. mansoni infection in previously identified persistent hot-spot communities?  

Countries: Kenya
Diseases: Schistosomiasis

Xenomonitoring Surveillance

Is molecular detection of schistosome infection (patent and pre-patent) in snails a useful tool for program managers as prevalence and intensity of infection in people approaches very low levels?

Countries: Tanzania
Diseases: Schistosomiasis

Interventions in Persistent Hot-Spots in Tanzania

How do villages which do not show substantial decreases in the prevalence of schistosomiasis despite repeated, high coverage mass drug administration (persistent hot-spot villages) differ from villages which show substantial decrease in prevalence across various factors (declining prevalence villages)?

Countries: Tanzania
Diseases: Schistosomiasis

Economic analysis in SCORE projects

Economic evaluation of SCORE projects with priority given to elimination studies

 

Countries: Tanzania | Cote d'Ivoire
Diseases: Schistosomiasis

Triple Drug Therapy for LF

Comparison of safety profile and acceptability between triple drug therapy (IVM,DEC,ALB) and standard two-drug therapy (DEC, ALB), plus STH evaluation.

TAS Strengthening in Haiti

From this study we hope to better understand whether MDA can be safely discontinued in EUs with ‘high TAS passing’ results, such as found in Limbé.

Countries: Haiti

TAS Strengthening in Tanzania

To evaluate strategies to improve the sensitivity of the TAS for detecting evidence of recent lymphatic filariasis transmission in an evaluation unit (EU). The TAS Strengthening Study in Tanzania is designed to assess additional indicators that may be added to the current TAS platform in order to strengthen the resulting stopping or surveillance decisions. A comprehensive analysis will be conducted to understand the correlation between antigen and antibody in adults and children with the mosquito data. A spatial analysis looking at microfoci of infection will also be conducted. Because the EU is also endemic for onchocerciasis, the new Ov16 monoplex RDT was used in the field. The Wb123 and Ov16 antibodies were assessed via ELISA in the NIMR lab in Tanga and the results will soon be compiled.  Xenomonitoring work to assess Culex and Anopheles mosquitoes, as well as black flies, is underway.

The results from this study will be combined into a multi-country analysis and are expected to help inform WHO guidance on stopping and surveillance for LF. 

Countries: Tanzania

Triple Drug Therapy (India)

To determine the frequency, type and severity of adverse events following triple-drug therapy (IVM+DEC+ALB, IDA) compared to the standard two-drug treatment (DEC+ALB, DA) in infected and uninfected individuals in a community.

To compare the efficacy of IDA vs. DA administered in communities for clearance of Mf and filarial antigenemia (Ag) in cohort and effectiveness (prevalence) in community settings. To assess the presence and intensity of filarial infection on the frequency and severity of adverse events. To compare community acceptance of MDA with IDA vs. DA.

Countries: India

LFTAS + Biplex + DBS in Oncho endemic areas in Cameroon

To assess if LF TAS is a valid platform to integrate Onchocerciasis transmission assessment surveys, using the same age group (6-7 years old) and the same prevalence threshold (<2%) that the LF programs utilize.

1. To perform the TAS for LF for stopping LF MDA and use it as platform for Oncho impact assessment.
2. To assess the level of endemicity of Oncho following MDAs in hypo and meso & hyper endemic districts.
3. To study the performance of Wb123/Ov16 Biplex rapid diagnostic test (RDT) to assess Oncho and LF transmission interruption.

Countries: Cameroon

Develop epidemiological and entomological methods to asses verification of transmission interruption of Onchocerciasis in Equatorial Guinea- Africa

After two decades of onchocerciasis control activities in Bioko island, transmission is expected to be interrupted. This study aims to demonstrate that WHO criteria to verify transmission interruption have been met. It also aims to standardize the reading of RDTs, particularly the FTS and Ov16, and reduce the potential for human error.

Countries: Equatorial Guinea

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