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Determining end markers for stopping MDA for Trachoma in Malawi

Currently MDA is stopped when TF in children aged 1-9 years is below 5%. However, the relationship between TF, presence of infection and antibody has not been studied in a sufficient number of settings to enable predictions of outcome to be confidently made based on baseline prevalence, intervention coverage, and the prevalence of disease and infection at the time of impact survey. There are several districts in Malawi with TF prevalence between 5 and 9.9% which are eligible for one year of interventions, including a single round of MDA. This study will add important data to be used to model outcomes of interventions conducted by trachoma elimination programs, and in particular, help develop operational guidelines for stopping MDA.

Countries: Malawi | Malawi | Malawi
Diseases: Trachoma

Testing New RDT Formats to Improve Wb123 Test Sensitivity

To test alternative rapid diagnostic test (RDT) formats for the Wb123 rapid test. In field trials, the current test format was less sensitive that FTS in post-MDA settings whereas alternative Wb123 test formats (ELISA, multiplex) were more sensitive. Our group uses new detection systems, based on nanoshells, to improve RDT performance. 

District Mapping Onchocerciasis, Lymphatic Filariasis, and Loiasis in Gabon

To define a cost-effective strategy to map Ivermectin-naïve districts for Onchocerciasis, Lymphatic Filariasis, and Loiasis in the context of elimination of these NTDs

Countries: Gabon | Gabon | Gabon

Estimating Population Denominators and Coverage of Mass Drug Administration Using Polio’s Vaccination Tracking System

To determine the viability of utilizing the polio program’s Vaccination Tracking System (VTS) to generate more accurate population, drug requirement and coverage estimates in NTD programs

Countries: Nigeria
Diseases: Trachoma

Serological indicators to measure the impact of the NTD control program on onchocerciasis in 3 distinct settings in Tanzania

To compare Ov16 ELISA and Ov16 rapid diagnostic test results, and better understand the significance of Ov16 serology in hypo-, meso- and hyper-endemic settings post-treatment.

Countries: Tanzania
Diseases: Onchocerciasis

Evaluation of Biplex RDT in Tshopo Province, DRC

The primary objective for this request is to evaluate the performance of the Biplex RDT in a cohort of 500 people previously tested for oncho and LF in 2014 (3-year follow up). The evaluation of the Biplex is an add-on to a study that will conduct a longitudinal follow up on a cohort of 500 people from the Tshopo Province. The primary outcomes are serology and clinical manifestations of onchocerciasis, This study also evaluates serology, parasitology and clinical manifestations for other filarial infections, mainly LF, Loa and Mansonella.

Countries: Dem. Rep. of Congo

The Global Atlas of Podoconiosis

Through funding from the Wellcome Trust to develop a global atlas of podoconiosis. We aim to advance new knowledge on the geographical distribution and spatial epidemiology of the disease.

i. Conduct national cross-sectional surveys in selected countries to validate the environmental predictive model developed using the mapping data in Ethiopia.

ii. Create evidence consensus maps, develop risk maps and ground-truthing work and delineate the spatial distribution and geographical limits of podoconiosis globally.

iii. Estimate the global burden of podoconiosis by quantifying the number affected, the population at risk and DALYs attributable.

iv. Estimate how much it will cost to control or eliminate podoconiosis globally.

 

Countries: Ethiopia | Cameroon | Rwanda | Uganda | Burundi | India
Diseases: Podoconiosis

Identification of endemic plants with potential for lymphoedema treatment.

Do endemic Ethiopian plant extracts have potential for use in lymphoedema management?

Countries:

Epidemiological mapping of mycetoma in Sudan

What is the distribution of mycetoma in Sudan?

Countries:
Diseases: Mycetoma

Development of a community-based mycetoma early detection programme

Can behavioural change communication lead to earlier presentation of mycetoma in rural Sudan?

Countries:
Diseases: Mycetoma

Understanding scabies transmission and outbreaks in rural Ethiopia

Can routine reports be used to identify hot spots of scabies transmission?

Countries:
Diseases: Scabies

Development of a diagnostic device for podoconiosis

Can bioielectrical impedance spectroscopy (BIS) identify patients with podoconiosis lymphoedema?

Countries:
Diseases: Podoconiosis

Integration and scale up of community-based holistic care package for people with lymphoedema in Ethiopia

What are the key elements that constitute optimal physical and psychosocial care for lymphoedema of many causes?

How (and to what extent) does integration of the lymphoedema intervention occur in the different ‘functions’ of the health system? What are the critical factors that influence the process of integration?

Countries:

DeWorm3 Implementation Science

The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of STH interventions.

The purpose of DeWorm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. Research methods include: (1) stakeholder mapping and network analysis, (2) qualitative research, (3) structural readiness surveys, (4) process mapping, and (5) economic evaluation (costing and cost-effectiveness). 

 Implementation science research aims include:

1)To systematically identify stakeholders influencing standard of care targeted and community-wide MDA and map their potential role and involvement in scale-up of community-wide MDA for STH.

2)To identify implementation-related barriers and facilitators to community-wide MDA for STH from the perspective of various stakeholders.

3)To quantify the readiness of the health system to deliver community-wide MDA for STH programs.

4)To map the intervention delivery process and identify any discrepancies between planned and implemented activities in order to optimize the trial intervention.

5)To compare the financial and economic costs and incremental cost-effectiveness of community-wide and targeted MDA for STH in the short- and long-term.

Countries: Benin | Malawi | India

Starworms study

The Starworms project aims to strengthen the monitoring and surveillance of drug efficacy and anthelmintic resistance in soil-transmitted helminth (STH) programs. As such, it will support deworming programs in their quest to eliminate STHs as a public health problem by 2020. The specific objectives are (1) to validate diagnostic tools to monitor drug efficacy and the spread of anthelmintic resistance, (2) to create a surveillance system that monitors the global patterns of drug efficacy and spread of anthelmintic resistance in STH programs, and (3) to develop supporting tools to plan, analyze and follow up on surveys on drug efficacy and the spread of anthelmintic resistance.

Studies of Gene Expression Pattern of Glutathione-S-Transferase (OvGST1) in the host and vector Simulium damnosum s.l.

To study the glutathione-S-transferase (OvGST1) gene expression pattern in the life cycle stages critical for the establishment of infection by Onchocerca volvulus.

Countries: Nigeria
Diseases: Onchocerciasis

Adding Antibody Testing to Mini-TAS

To compare results from Brugia Rapid tests (in 3 districts) and FTS (in 2 districts) with Wb123 rapid tests and Wb123 and Bm14 ELISA testing.

Countries: Viet Nam

District Mapping Onchocerciasis, Lymphatic Filariasis, and Loiasis in Nigeria

To define a cost-effective and accurate method to map ivermectin-naïve districts for Onchocerciasis, Lymphatic Filariasis and Loiasis and identify districts eligible for safe treatment with ivermectin MDA.

Countries: Nigeria

Integrated Transmission Assessment Surveys (iTAS) and Onchocerciasis evaluation in areas of Co-Endemicity for both infections in Tanzania

To determine the validity and programmatic feasibility of an integrated transmission assessment survey (F-TAS), to be used to simultaneously assess Onchocerciasis (Oncho) and Lymphatic Filariasis (LF) prevalence in areas co-endemic for the two infections that have completed the recommended treatment for one or both infections.

Countries: Tanzania

STH Diagnostic Comparison: PCR vs. Kato-Katz, Uganda

To determine if a standardized multi-parallel-PCR assay is a more sensitive diagnostic tool for detecting Hookworm (Ancylostoma duodenale and Necator americanus), Trichuris trichiura, Ascaris lumbricoides, Strongyloides stercoralis, and Schistosoma mansoni prevalence compared to the Kato-Katz stool test.

Countries: Cameroon

The Impact of an Enhanced Antibiotic Treatment Regimen on Trachoma in Amhara, Ethiopia

What are the differences at 1 year post-baseline in the prevalence of trachoma and Ct infection in villages randomized to an enhanced antibiotic treatment regimen characterized by a routine community-wide MDA followed by two rounds of treatment targeted to children 6 months to 9 years in quick succession (1-2 weeks apart) compared to villages randomized to annual standard-of-care community-wide MDA?

Countries: Ethiopia
Diseases: Trachoma

Life on the edge: tackling Africa HAT on the edge of wilderness areas

LSTM |

Our proposal will study the interaction between humans, livestock and wildlife and the role of this transition zone in the transmission of trypanosomes at the edge of the Serengeti National Park in Tanzania. To assess whether focussed control of tsetse is effective, we will develop mathematical models of the transmission of trypanosomes in the transition zone from wildlife-dominated areas on the park boundaries through to livestock-dominated areas outside the parks. The models will enable us to predict the likely extent, duration and cost of interventions required to interrupt the transmission of trypanosomes at boundary areas. 

Countries: Tanzania

Molecular Characterisation of Anopheles gambiae Heme Oxygenase

LSTM |

Understanding how mosquitoes survive a blood meal

Countries:

Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake venom pathology and antivenom efficacy

LSTM |

Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake venom pathology and antivenom efficacy

Countries:
Diseases: Snakebite

Mechanism to reverse the neglect of snakebite victims

LSTM |

To understand the mechanism to reverse the neglect of snakebite victim

Countries:
Diseases: Snakebite

Use of tiny targets to control HAT in Chad

LSTM |

Explore the use of tiny targets to control Human African Trypanosomiasis (HAT) in Chad

Countries: Chad

Integrated HAT control - a model district in DRC

LSTM |

Determine the effectiveness of integrated control of Human African Trypanosomiasis (HAT) in a model district in DRC

Countries: Dem. Rep. of Congo

Effectiveness of tiny target technology in controlling tsetse vectors for HAT

LSTM |

To determine the effectiveness of tiny target technology in controlling tsetse vectors for Human African Trypanomiasis

Countries:

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