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Sustaining the Gains of NTD elimination programs through focused support of community drug distributors

To sustain the gains of active community drug distributors (CDDs) by enhancing their performance through intervention at the individual, community and primary health care center levels to reach NTD elimination and control goals.

Countries: Uganda | Cote d'Ivoire

Doxycycline for Clinical Management of Filarial Lymphedema (Mali)

Determine whether doxycycline treatment daily for 6 weeks improves clinical outcomes (swelling, acute attacks) in lymphedema patients.

Countries: Mali

Integrating use of point-of-care circulating cathodic antigen rapid diagnostic by community health workers during mass drug administration campaign to increase uptake of praziquantel treatment among adult populations in North-Western Tanzania

To assess if introducing point-of-care Circulating Cathodic Antigen rapid test to community health workers will increase access, compliance and coverage to treatment among adult individuals at Kome Island in North-Western Tanzania, an area on the Lake Victoria highly endemic for schistosomiasis

Countries: Tanzania
Diseases: Schistosomiasis

Does infection data add anything to our understanding of trachoma prevalence in low endemic areas?

To investigate prevalence of ocular chlamydial infection and associated risk factors in children aged 1-9 year in Manyoni district

Countries: Tanzania
Diseases: Trachoma

Development of a molecular diagnostic method for soil-transmitted helminthiases: Epidemiological implications for disease control

To improve STH detection by developing a reliable and easy to perform molecular diagnostic test for epidemiological surveillance and post-elimination monitoring of STH

Countries: Cameroon

Demand creation and services uptake push for onchocerciasis control in Cross River State, Nigeria

To increase onchocerciasis treatment coverage and to optimize service delivery through community mobilization, disease sensitization, training and strengthening of community health extension workers (CHEW), and community control advocates

Countries: Nigeria
Diseases: Onchocerciasis

Monitoring migrant groups as a post-treatment surveillance approach to contain the potential risk of lymphatic filaraisis re-emergence after stopping mass drug administration in Togo

In March 2016, the Republic of Togo submitted an application for validation of the elimination of LF as a public health problem. However, healthcare facility managers in some health regions – especially in the Savanes Region, have reported the presence of migrant groups from neighboring countries which are still endemic to LF – i.e. Ghana, Burkina Faso, Nigeria. Migrants arrive and reside temporarily but recurrently in some localities of these regions. They constitute hotspots that can be source of resurgence, mainly because the nationwide passive surveillance has been stopped in 2016. 

In order to track all population movements that constitute a potential risk to the Republic of Togo, the country proposes to set up a strategy for the identification of these groups, with the contribution of Neglected Tropical Disease (NTD) Focal Points, followed by the research of potential parasite carriers. Isolated cases discovered will be investigated in order to track all imported W. bancrofti. They will be treated, but if an effective hotspot is discovered, rounds of Albendazole and Ivermectin MDA will be implemented a follow up of infected individuals will be maintained. 

The purpose of this study is to contribute maintaining the end of LF transmission across the country.

Countries: Togo

Investigation of possible ongoing Schistosoma hybridization in Nigeria and implications for response to treatment

To investigate the presence and epidemiology of Schistosoma hybrids in Nigeria.

Countries: Nigeria
Diseases: Schistosomiasis

Field testing the use of 3D photographs of trachomatous trichiasis to train trachoma field graders

To evaluate 3D photographs of trachomatous trichiasis (TT) in the training and assessment of trachoma graders.

Countries: Ethiopia
Diseases: Trachoma

Long term outcome of the two most commonly used surgical procedures to treat trachomatous trichiasis (TT): PLTR vs BLTR

Ascertain whether the difference in outcome (measured in rate of post-operative trachomatous trichiasis, or TT), between the posterior lamellar tarsal rotation (PLTR) and bilamellar tarsal rotation (BLTR) is sustained at four years or whether they give different results from what has been found at 1 year.

Countries: Ethiopia
Diseases: Trachoma

Quality and quantity of post-epilation trichiatic lashes: a cohort study

To understand the nature (quality and quantity) of post epilation lashes and their visual significance in unoperated minor trachomatous trichiasis (TT) cases and case with post-operative trichiasis

Countries: Ethiopia
Diseases: Trachoma

District Mapping Onchocerciasis in Malawi

To assess the programmatic feasibility of and determine the most appropriate age group and sampling strategy for an oncho mapping survey for ivermectin-naïve areas

Countries: Malawi
Diseases: Onchocerciasis

Antibody Responses to Chlamydia trachomatis Antigens in Trachoma-Endemic Zones of Ethiopia

To analyze the relationships between the currently used indicator for impact assessments - prevalence of the clincial sign TF - and the prevalence of infection and antibody among 1-9 year old children in hyperendemic districts prior to mass drug administration

Countries: Ethiopia
Diseases: Trachoma

Doxycycline for Clinical Management of Filarial Lymphedema (Sri Lanka)

Determine whether doxycycline treatment daily for 6 weeks improves clinical outcomes (swelling, acute attacks) in lymphedema patients.

Countries: Sri Lanka

Determining end markers for stopping MDA for Trachoma in Malawi

Currently MDA is stopped when TF in children aged 1-9 years is below 5%. However, the relationship between TF, presence of infection and antibody has not been studied in a sufficient number of settings to enable predictions of outcome to be confidently made based on baseline prevalence, intervention coverage, and the prevalence of disease and infection at the time of impact survey. There are several districts in Malawi with TF prevalence between 5 and 9.9% which are eligible for one year of interventions, including a single round of MDA. This study will add important data to be used to model outcomes of interventions conducted by trachoma elimination programs, and in particular, help develop operational guidelines for stopping MDA.

Countries: Malawi | Malawi | Malawi
Diseases: Trachoma

Testing New RDT Formats to Improve Wb123 Test Sensitivity

To test alternative rapid diagnostic test (RDT) formats for the Wb123 rapid test. In field trials, the current test format was less sensitive that FTS in post-MDA settings whereas alternative Wb123 test formats (ELISA, multiplex) were more sensitive. Our group uses new detection systems, based on nanoshells, to improve RDT performance. 

District Mapping Onchocerciasis, Lymphatic Filariasis, and Loiasis in Gabon

To define a cost-effective strategy to map Ivermectin-naïve districts for Onchocerciasis, Lymphatic Filariasis, and Loiasis in the context of elimination of these NTDs

Countries: Gabon | Gabon | Gabon

Estimating Population Denominators and Coverage of Mass Drug Administration Using Polio’s Vaccination Tracking System

To determine the viability of utilizing the polio program’s Vaccination Tracking System (VTS) to generate more accurate population, drug requirement and coverage estimates in NTD programs

Countries: Nigeria
Diseases: Trachoma

Serological indicators to measure the impact of the NTD control program on onchocerciasis in 3 distinct settings in Tanzania

To compare Ov16 ELISA and Ov16 rapid diagnostic test results, and better understand the significance of Ov16 serology in hypo-, meso- and hyper-endemic settings post-treatment.

Countries: Tanzania
Diseases: Onchocerciasis

Evaluation of Biplex RDT in Tshopo Province, DRC

The primary objective for this request is to evaluate the performance of the Biplex RDT in a cohort of 500 people previously tested for oncho and LF in 2014 (3-year follow up). The evaluation of the Biplex is an add-on to a study that will conduct a longitudinal follow up on a cohort of 500 people from the Tshopo Province. The primary outcomes are serology and clinical manifestations of onchocerciasis, This study also evaluates serology, parasitology and clinical manifestations for other filarial infections, mainly LF, Loa and Mansonella.

Preliminary Findings and Lessons Learned

This study built on an existing onchocerciasis longitudinal follow-up study in Banalia community, Tshopo province, DRC. The location is co-endemic for Oncho, LF, Loa loa and Mansonella perstans.  500 people previously tested in 2014 have been followed up and were retested in 2017.   A total of 239, out of 500, agreed to participate in the follow-up activity and provided a blood specimen.  Thirty percent were positive by skin snip, 3% were positive by FTS, 15% were found to have loa (thick blood film) and 41% had M. perstans.  Ov16 ELISA testing found 67% positive, while the Biplex found 38% Ov16 positive. The sensitivity of the Ov16 biplex compared to the ELISA was 53%.

Countries: Dem. Rep. of Congo

The Global Atlas of Podoconiosis

Through funding from the Wellcome Trust to develop a global atlas of podoconiosis. We aim to advance new knowledge on the geographical distribution and spatial epidemiology of the disease.

i. Conduct national cross-sectional surveys in selected countries to validate the environmental predictive model developed using the mapping data in Ethiopia.

ii. Create evidence consensus maps, develop risk maps and ground-truthing work and delineate the spatial distribution and geographical limits of podoconiosis globally.

iii. Estimate the global burden of podoconiosis by quantifying the number affected, the population at risk and DALYs attributable.

iv. Estimate how much it will cost to control or eliminate podoconiosis globally.

 

Countries: Ethiopia | Cameroon | Rwanda | Uganda | Burundi | India
Diseases: Podoconiosis

Identification of endemic plants with potential for lymphoedema treatment.

Do endemic Ethiopian plant extracts have potential for use in lymphoedema management?

Countries:

Epidemiological mapping of mycetoma in Sudan

What is the distribution of mycetoma in Sudan?

Countries:
Diseases: Mycetoma

Development of a community-based mycetoma early detection programme

Can behavioural change communication lead to earlier presentation of mycetoma in rural Sudan?

Countries:
Diseases: Mycetoma

Understanding scabies transmission and outbreaks in rural Ethiopia

Can routine reports be used to identify hot spots of scabies transmission?

Countries:
Diseases: Scabies

Development of a diagnostic device for podoconiosis

Can bioielectrical impedance spectroscopy (BIS) identify patients with podoconiosis lymphoedema?

Countries:
Diseases: Podoconiosis

Integration and scale up of community-based holistic care package for people with lymphoedema in Ethiopia

What are the key elements that constitute optimal physical and psychosocial care for lymphoedema of many causes?

How (and to what extent) does integration of the lymphoedema intervention occur in the different ‘functions’ of the health system? What are the critical factors that influence the process of integration?

Countries:

DeWorm3 Implementation Science

The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of STH interventions.

The purpose of DeWorm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. Research methods include: (1) stakeholder mapping and network analysis, (2) qualitative research, (3) structural readiness surveys, (4) process mapping, and (5) economic evaluation (costing and cost-effectiveness). 

 Implementation science research aims include:

1)To systematically identify stakeholders influencing standard of care targeted and community-wide MDA and map their potential role and involvement in scale-up of community-wide MDA for STH.

2)To identify implementation-related barriers and facilitators to community-wide MDA for STH from the perspective of various stakeholders.

3)To quantify the readiness of the health system to deliver community-wide MDA for STH programs.

4)To map the intervention delivery process and identify any discrepancies between planned and implemented activities in order to optimize the trial intervention.

5)To compare the financial and economic costs and incremental cost-effectiveness of community-wide and targeted MDA for STH in the short- and long-term.

 

Countries: Benin | Malawi | India

Starworms study

The Starworms project aims to strengthen the monitoring and surveillance of drug efficacy and anthelmintic resistance in soil-transmitted helminth (STH) programs. As such, it will support deworming programs in their quest to eliminate STHs as a public health problem by 2020. The specific objectives are (1) to validate diagnostic tools to monitor drug efficacy and the spread of anthelmintic resistance, (2) to create a surveillance system that monitors the global patterns of drug efficacy and spread of anthelmintic resistance in STH programs, and (3) to develop supporting tools to plan, analyze and follow up on surveys on drug efficacy and the spread of anthelmintic resistance.

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